{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:19Z","timestamp":1787015719496,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bupropion is used as smoking cessation drug and antidepressant. Drug overdose has multi\u2010system involvement including neurotoxicity and cardiovascular collapse. Use of haemoperfusion in bupropion toxicity is generally not useful, however in life\u2010threatening condition it could be a life saver. We reported a case of 30s male with bupropion overdose who ingested 29 tablets of 300\u2010mg extended\u2010release bupropion. The patient had status epilepticus with prolonged QTc interval. He remained unconscious with abnormal jerky movements despite multiple high dose antiepileptic drugs. A 4\u2010h session of resin adsorber haemoperfusion was done with rapid improvement of consciousness within 24\u2009h and seizure control confirmed by electroencephalogram. In severe cases with early presentation, haemoperfusion may be useful to prevent further toxicity.<\/jats:p>","DOI":"10.1111\/nep.14417","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:59:31Z","timestamp":1733795971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe bupropion intoxication successfully treated with resin adsorber haemoperfusion"],"prefix":"10.1111","volume":"30","author":[{"given":"Anyarin","family":"Wannakittirat","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine Naresuan University  Phitsanulok Thailand"},{"name":"Excellence Centre for Critical Care Nephrology King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aschariya","family":"Wipattanakitcharoen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somjet","family":"Tosamran","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanittha","family":"Yimsangyad","sequence":"additional","affiliation":[{"name":"Excellence Centre for Critical Care Nephrology King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerachai","family":"Chaijamorn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttha","family":"Lumlertgul","sequence":"additional","affiliation":[{"name":"Excellence Centre for Critical Care Nephrology King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadudee","family":"Peerapornratana","sequence":"additional","affiliation":[{"name":"Excellence Centre for Critical Care Nephrology King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Laboratory Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chusak","family":"Limotai","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Comprehensive Epilepsy Centre of Excellence, Division of Neurology, Department of Medicine, Faculty of Medicine King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-8132","authenticated-orcid":false,"given":"Nattachai","family":"Srisawat","sequence":"additional","affiliation":[{"name":"Excellence Centre for Critical Care Nephrology King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, and Excellence Centre in Critical Care Nephrology Chulalongkorn University  Bangkok Thailand"},{"name":"Academy of Science Royal Society of Thailand  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.063107"},{"key":"e_1_2_3_3_1","unstructured":"Wellbutrin XL\u00ae.Bupropion hydrochloride (package insert). 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