{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:27:19Z","timestamp":1780619239743,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The case report presents a male patient in his mid\u201060s with a history of hypertension, benign prostatic hyperplasia and chronic kidney disease (CKD). He presented with gradually increasing serum creatinine levels and hyperglobulinemia, leading to suspicion of multiple myeloma. However, subsequent testing revealed features consistent with systemic lupus erythematosus (SLE) and IgG4\u2010related kidney disease (IgG4\u2010RKD). The patient's laboratory results included anaemia, positive ANA and anti\u2010dsDNA and elevated serum IgG4 levels. A kidney biopsy showed extensive interstitial fibrosis, plasma cell infiltration and a high number of IgG4\u2010positive plasma cells, suggesting the diagnosis of IgG4\u2010RKD overlapping with SLE. Treatment involved prednisolone, mycophenolate mofetil for IgG4\u2010RKD and hydroxychloroquine for SLE. The patient's case highlights the challenges in diagnosing overlapping IgG4\u2010RKD and SLE. The current criteria for diagnosing these diseases may be complicated by atypical presentations, leading to potential diagnostic confusion. This report underscores the importance of histopathological confirmation and comprehensive diagnostic criteria to differentiate between overlapping autoimmune conditions. Immunosuppressive therapy remains the cornerstone for managing both IgG4\u2010related disease and SLE, with treatment tailored based on disease severity and organ involvement. The patient's response to treatment and follow\u2010up monitoring are crucial for assessing outcomes and adjusting management to minimise disease relapse and therapy\u2010related complications.<\/jats:p>","DOI":"10.1111\/nep.14429","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T11:11:16Z","timestamp":1736593876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Challenging Case of <scp>IgG4<\/scp>\u2010Related Kidney Disease Accompanied With Positive Serologic Tests of Lupus Erythematosus"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1507-6418","authenticated-orcid":false,"given":"Wankawee","family":"Jeerangsapasuk","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Faculty of Medicine Thammasat University  Pathumthani Thailand"},{"name":"60th Anniversary HRH Maha Chakri Sirindhorn 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Internal Medicine, Faculty of Medicine Thammasat University  Pathumthani Thailand"},{"name":"60th Anniversary HRH Maha Chakri Sirindhorn Hemodialysis Center Thammasat University Hospital  Pathumthani 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