{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:28:20Z","timestamp":1788672500929,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Muscle symptoms including myalgia are common in patients with anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis (AAV). Muscle biopsy (MB) is sometimes used in the diagnosis of AAV, but which AAV patients benefit from MB remains unclear. We retrospectively assessed the clinical characteristics of Japanese AAV patients who underwent MB and examined the relationship between MB showing positive results for muscular vasculitis and kidney involvement. We enrolled all 38 of the 118 patients with AAV who also underwent MB. Clinical characteristics and histopathological findings on kidney biopsies were assessed in patients with MB showing positive or negative results for muscular vasculitis. Among the 38 patients, 34 (89.5%) were diagnosed with microscopic polyangiitis, and 17 patients (44.7%) showed positive MB. Myalgia and edema of the lower extremities were observed in 12\u2009MB\u2010positive patients, higher proportions than seen in MB\u2010negative patients (70.6% vs. 38.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.046 and 70.6% vs. 33.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.022, respectively). Kidney involvement was more frequent in MB\u2010positive patients (70.6%) than in MB\u2010negative patients (28.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.010). Twelve of the 38 patients with MB underwent kidney biopsy. Proportions of crescents or vascular fibrinoid necrosis were higher in MB\u2010positive patients than in MB\u2010negative patients (83% vs. 33% and 67% vs. 20%, respectively). Myalgia and edema of the lower extremities may offer a guide to the utility of MB. Glomerulonephritis should be considered when muscular vasculitis is confirmed by MB.<\/jats:p>","DOI":"10.1111\/nep.70021","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T23:23:07Z","timestamp":1742340187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Characteristics of Anti\u2010Neutrophil Cytoplasmic Antibody\u2010Associated Vasculitis Patients Proven by Muscle Biopsy and Its Relevance to Kidney Involvement"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-8513","authenticated-orcid":false,"given":"Shunichiro","family":"Hanai","sequence":"first","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-2855","authenticated-orcid":false,"given":"Yoshiaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakako","family":"Tanaka\u2010Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-9799","authenticated-orcid":false,"given":"Daiki","family":"Nakagomi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University of Yamanashi Hospital  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac623"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010209133"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04652-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100390"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1086431"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa233"},{"key":"e_1_2_9_8_1","first-page":"984","article-title":"Utility of Lower Extremity Magnetic Resonance Imaging Followed by Muscle Biopsy for Myeloperoxidase\u2010Antineutrophil Cytoplasmic Antibodies Positive Antineutrophil Cytoplasmic Antibody\u2010Associated Vasculitis: A Single\u2010Centre Study","volume":"41","author":"Jinno S.","year":"2023","journal-title":"Clinical and Experimental 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