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To better understand the epidemiology and clinical implications of AKI in hospitalised cancer patients, this study was designed to determine the incidence of AKI, identify risk factors for AKI and assess the impact of AKI on in\u2010hospital outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of 68\u2009379 cancer admissions in 2019. AKI incidence, risk factors (demographics, comorbidities and clinical characteristics), and impact on in\u2010hospital mortality and length of stay were assessed. Logistic regression was employed to identify the risk factors for AKI. Survival analysis was conducted using the Cox proportional hazards model, with log\u2010rank statistics used to assess survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 68\u2009379 eligible cancer admissions, 7734 AKI cases were recognised with an incidence rate of 11.3%. The highest rates were observed in renal cancer (40.1%), ureter cancer (27.9%) and multiple myeloma (16.1%). Clinical risk factors such as age\u2009&gt;\u200950\u2009years, body mass index &lt;\u200918.5\u2009kg\/m<jats:sup>2<\/jats:sup>, and hyperuricemia were significantly associated with hospital\u2010acquired AKI compared to the non\u2010AKI group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In cases of severe community\u2010acquired AKI, significant differences in hypertension, anaemia and leukocyte elevation were also observed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The mortality rate was notably higher in AKI patients, especially in the severe AKI subgroup. The length of stay was markedly prolonged in patients with hospital\u2010acquired and severe AKI, further underscoring the clinical burden of this complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospitalised cancer patients experience a high incidence of AKI. Identifying and mitigating risk factors may improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.70025","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:03:48Z","timestamp":1744002228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute Kidney Injury in Hospitalised Cancer Patients: Incidence, Risk Factors and Outcomes"],"prefix":"10.1111","volume":"30","author":[{"given":"Yanting","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Nephrology Laboratory of Renal Disease, Pu Tuo Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Department of Nephrology, Xiamen Branch Zhongshan Hospital, Fudan University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-1366","authenticated-orcid":false,"given":"Genwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Laboratory of Renal Disease, Pu Tuo Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xiamen Branch Zhongshan Hospital, Fudan University  Xiamen China"},{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Nephrology Clinical Quality Control Center of Xiamen  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02724-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.19.042"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010015\u20103934\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.02.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2016.09.055"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-020-01039-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4907"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1613984"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2346268"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115323"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102019\u2010000467"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090740"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2972275"},{"key":"e_1_2_11_17_1","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes Acute Kidney Injury Work Group. 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