{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:07Z","timestamp":1790947927917,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>BKPyV\u2010DNAemia occurs in up to 30% of kidney transplant recipients (KTRs), with graft\u2010threatening BKPyV\u2010nephropathy in up to 10%. Risk factors for BKPyV\u2010DNAemia, BKPyV\u2010nephropathy, and associated graft loss are incompletely described. We sought to determine the prevalence, risk factors for, and long\u2010term impact of BKPyV\u2010DNAemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre retrospective study of adult KTRs between 2010 and 2018. We used logistic regression to determine odds ratios (OR) of BKPyV\u2010DNAemia, and survival analysis to assess the impact of BKPyV\u2010DNAemia on graft and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 522 patients, 100 (19%) developed BKPyV\u2010DNAemia and 43 (8.2%) developed BKPyV\u2010nephropathy, resulting in the loss of two grafts. Factors associated with the development of BKPyV\u2010DNAemia were non\u2010Caucasian ethnicity (OR 1.76, CI 0.98\u20133.16), pre\u2010transplant diabetes (OR 2.06, CI 1.02\u20134.14) and HLA mismatch of 3\/6 or 4\/6 (OR 2.37, CI 1.06\u20135.56) and HLA mismatch of 5\/6 and 6\/6 (OR 2.53, CI 1.20\u20135.63). Additionally, a greater than 25\u2009mg per day prednisolone dose following acute transplant and acute rejection in the first month post\u2010transplant was associated with an increased risk of BKPyV\u2010DNAemia (OR 3.06, CI 1.66\u20136.06 and OR 2.36, CI 1.16\u20134.75 respectively). Over a 10\u2010year follow\u2010up, the development of BKPyV\u2010DNAemia and BKPyV\u2010nephropathy was not associated with reduced graft or patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While BKPyV\u2010DNAemia and BKPyV\u2010nephropathy remain prevalent in KTR, there were low rates of associated graft loss and no demonstrable impact on long\u2010term graft or patient survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.70058","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:29:37Z","timestamp":1748993377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for the Development of <scp>BK<\/scp> Polyomavirus and Treatment Outcomes in Kidney Transplant Recipients: An 8\u2010Year Retrospective Cohort Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Alyssa","family":"Pradhan","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-107X","authenticated-orcid":false,"given":"Melanie","family":"Wyld","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Renal and Transplant Medicine Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Department of Renal Medicine Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Davis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"NSW Health Pathology RPA  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushani","family":"Jayasinghe","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Nephrology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Wyburn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Renal Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.12659\/aot.934738"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13071290"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.14134"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12687"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000004976"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081616"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.12.020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12644"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13528"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000003801"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.377"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13030487"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(07)61602\u2010x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.259"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.11.028"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2015.8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.06.040"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.08.036"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12681"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173779"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020150"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2010.03310.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2012.04320.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31828423cd"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.06.038"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12985"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010023\u201008043\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20102277.2007.00523.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12134"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12530"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.08420813"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T23:13:53Z","timestamp":1750634033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/nep.70058"],"URL":"https:\/\/doi.org\/10.1111\/nep.70058","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70058"}}