{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:08:54Z","timestamp":1791590934155,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the case of a 32\u2010year\u2010old man with a family history of nail patella syndrome (NPS) who presented with severe kidney dysfunction, hematuria, and proteinuria. A renal biopsy was performed to rule out other kidney diseases and obtain information on the possibility of future renal transplantation, as the renal morphology was relatively preserved and abnormal urinary findings indicative of nephritis. The scarcity of viable glomeruli for conventional transmission electron microscopy (TEM) prompted us to use low\u2010vacuum scanning electron microscopy (LV\u2010SEM) on light microscopy samples. LV\u2010SEM analysis revealed characteristic glomerular basement membrane (GBM) alterations, including a coarse meshwork structure and a ragged pattern, similar to the GBM changes observed in Alport syndrome. These findings, combined with genetic testing results, confirmed the diagnosis of NPS\u2010associated nephropathy. This case represents the first reported use of LV\u2010SEM for observing and diagnosing NPS\u2010associated nephropathy, demonstrating its potential as a valuable diagnostic tool wherein sample availability or quality limits the conventional TEM.<\/jats:p>","DOI":"10.1111\/nep.70062","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:49:16Z","timestamp":1749538156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The First Observation and Diagnosis of Nail\u2010Patella Syndrome Using <scp>LV<\/scp>\u2010<scp>SEM<\/scp>: <scp>GBM<\/scp> Abnormalities Mimicking Alport Syndrome"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1239-6551","authenticated-orcid":false,"given":"Hiroki","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Faculty of Medicine Tohoku Medical and Pharmaceutical University 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