{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:08:32Z","timestamp":1788322112846,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Thrombotic microangiopathy (TMA) is a rare but potentially severe condition induced by cancer treatments, including angiogenesis inhibitors and immune checkpoint inhibitors. This case report presents the first documented instance of renal\u2010limited TMA potentially triggered by fruquintinib and tislelizumab in a patient with metastatic rectal cancer. A 60\u2010year\u2010old woman with stage IIIB rectal cancer developed nephrotic syndrome following treatment with fruquintinib and tislelizumab. She had no prior history of kidney disease but presented with lower limb oedema and proteinuria. Renal biopsy\u2013confirmed TMA with focal segmental glomerulosclerosis. Following discontinuation of the drugs and management of hypertension, her renal function improved and proteinuria resolved. This case underscores the importance of monitoring renal function in patients with cancer receiving fruquintinib and immune checkpoint inhibitors, as TMA may develop even after short\u2010term exposure. Early detection through renal biopsy and prompt withdrawal of the causative agents may prevent irreversible renal damage. Further research is required to better understand the pathophysiology of TMA in this context and to inform management strategies.<\/jats:p>","DOI":"10.1111\/nep.70067","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T03:49:07Z","timestamp":1750218547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Renal\u2010Limited Thrombotic Microangiopathy Induced by Fruquintinib and Tislelizumab: A Case Report"],"prefix":"10.1111","volume":"30","author":[{"given":"Qiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Tan","sequence":"additional","affiliation":[{"name":"Development &amp; Planning Office Affiliated Hospital of Hebei University  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology Chengde Nursing Vocational College  Chengde Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beining","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7488-0532","authenticated-orcid":false,"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine, Hebei University  Baoding Hebei China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1088031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa195"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00212"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo\u201023\u2010931"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101081"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063\u2010022\u201000984\u20108"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.02.340"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13716"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm311"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000000207"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073825"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18\u20100045"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210565"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.Cir\u201019\u20100360"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010020\u201002676\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115112"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2023.09.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2016.08.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.10.029"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae073"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2336069"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13943"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1264874"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010024\u201003598\u20108"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130651"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/23993693221147769"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003810"}],"updated-by":[{"DOI":"10.1111\/nep.70130","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000}}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T23:13:53Z","timestamp":1750634033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/nep.70067"],"URL":"https:\/\/doi.org\/10.1111\/nep.70067","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70067"}}