{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:03:58Z","timestamp":1764306238605,"version":"3.44.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Long\u2010term health outcomes in living kidney donors (LKDs) are generally favourable. However, recent studies suggest a slightly increased malignancy risk when compared to the general healthy population. Malignancies are influenced by environmental and racial factors; nonetheless, descriptive epidemiological studies on malignancy incidence in LKDs in Asia are lacking. In this study, we aimed to investigate the incidence and characteristics of post\u2010donation malignancies in LKDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study included 196 LKDs who underwent nephrectomies between 2008 and 2023. LKDs were categorised into new\u2010onset malignancy and non\u2010malignancy cohorts. Postoperative malignancy surveillance combined population\u2010based cancer screenings, employer\u2010sponsored health examinations, self\u2010paid health checkups, and active surveillance. Baseline characteristics, cancer types, outcomes, and the correlation between cancer incidence and postoperative albuminuria were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen LKDs (9.2%) developed malignancies over a mean follow\u2010up of 6.7\u2009\u00b1\u20094.1\u2009years, with an incidence rate of 13.6 per 1000 person\u2010years. The most common cancers were gastric, colorectal, and prostate. Malignancy was more frequent in older donors, males, and those with postoperative hypertension. Most cases were detected at an early stage, allowing curative treatment. The most common diagnostic category of cancer identified was performed as part of our institution's active surveillance. No notable correlation was observed between albuminuria and cancer incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While some LKDs developed post\u2010donation malignancies, appropriate and balanced cancer surveillance is essential in managing LKDs, in whom the principle of \u201cdo no harm\u201d must be upheld. Establishing a structured system, including public screening programmes and LKD\u2010specific surveillance, would help ensure donor safety and long\u2010term health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.70108","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T23:34:01Z","timestamp":1755128041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidence of Malignancy in Post\u2010Donation Living Kidney Donors: A Single\u2010Center, Retrospective Cohort Study in Japan"],"prefix":"10.1111","volume":"30","author":[{"given":"Kana","family":"Shirai","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3933-9370","authenticated-orcid":false,"given":"Masatomo","family":"Ogata","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Murata\u2010Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Pharmacy St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Sasaki Urology Clinic  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Urology St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Shibagaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-5347","authenticated-orcid":false,"given":"Masahiko","family":"Yazawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"},{"name":"Department of Internal Medicine Yokohama General Hospital  Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001770"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804883"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318192dc95"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285141"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.460"},{"key":"e_1_2_9_7_1","first-page":"473","article-title":"Onco\u2010Nephrology: Cancer, Chemotherapy and Kidney","volume":"39","author":"Francisco A. 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M.","year":"2019","journal-title":"Nefrolog\u00eda"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1053\/j.ajkd.2023.04.014","article-title":"Onconephrology: Core Curriculum 2023","volume":"82","author":"Yarandi N.","year":"2023","journal-title":"American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0441-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-024-02476-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17082"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000157343.27949.9F"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.1439"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35458"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-1118"},{"key":"e_1_2_9_17_1","first-page":"10","article-title":"Association of Hypertension and Organ\u2010Specific Cancer: A Meta\u2010Analysis","volume":"10","author":"Connaughton M.","year":"2022","journal-title":"Health"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-1235"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78885"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.02.020"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45014-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001819"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15433-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs145"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T23:13:52Z","timestamp":1755645232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/nep.70108"],"URL":"https:\/\/doi.org\/10.1111\/nep.70108","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70108"}}