{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T01:40:28Z","timestamp":1764639628878,"version":"3.46.0"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Adolescents and young adults (AYAs) are increasingly utilising kidney health care services. However, there is no data on the impact of kidney transition clinics, as well as the AYA spectrum of kidney diseases, in South Africa (SA). This study evaluates kidney outcomes and patient survival amongst AYA patients attending a dedicated kidney AYA clinic (KAYAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 5\u2010year retrospective study included AYA (aged 13\u201325) with kidney disease, attending a tertiary nephrology service. A comparative analysis of outcomes between patients who attended the KAYAC and those attending the standard\u2010of\u2010care adult kidney clinics was performed. The primary composite outcome assessed included doubling of creatinine, reduction in eGFR &gt;\u200940%, kidney failure, requirement for kidney replacement therapy, or death. Logistic regression evaluated the associations between relevant variables, death, and loss to follow\u2010up (LTFU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AYA cohort consisted of 292 patients: 111 (38.0%) attended KAYAC and 181 (62.0%) attended adult clinics. Glomerular diseases (72.6%), congenital urinary tract anomalies (10.6%) and hereditary conditions (8.2%) were the most common causes of kidney disease. The KAYAC group had delayed progression to kidney failure with an improved composite outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), lower mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046) and less LTFU (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Both groups demonstrated high rates of non\u2010adherence, with a prevalence of 33.9% in the total cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AYA are a unique population who could benefit from KAYAC transition clinics. A dedicated KAYAC has been found to be associated with better kidney outcomes, lower mortality and less LTFU, underscoring its critical role in resource\u2010limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70110","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T23:55:44Z","timestamp":1756166144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of a Dedicated Kidney Adolescent and Young Adult Clinic (\n                    <scp>KAYAC<\/scp>\n                    ) in South Africa"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5053-5495","authenticated-orcid":false,"given":"Zibya","family":"Barday","sequence":"first","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Wearne","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika S. W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mignon","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Paediatrics, Red Cross War Memorial Children's Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Hoare","sequence":"additional","affiliation":[{"name":"Psychiatry and Mental Health Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Manning","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Pretorius","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-8581","authenticated-orcid":false,"given":"Bianca J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Nephrology and Hypertension, Department of Medicine, Groote Schuur Hospital University of Cape Town  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cAdolescent and Young Adult Health WHO \u201d(2022) WHO Fact Sheet https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/adolescents\u2010health\u2010risks\u2010and\u2010solutions."},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization \u201cAdolescent Mental Health \u201d(2021) WHO Fact Sheet https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/adolescent\u2010mental\u2010health."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAPEDIATRICS.2020.0311"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.e382"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(17)30057\u20108"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321854"},{"key":"e_1_2_10_8_1","first-page":"425","article-title":"Brain Development During Adolescence","volume":"110","author":"Konrad K.","year":"2013","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00243639.2016.1211863"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1467\u20107687.2006.00579.X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2000.00121.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103046.2010.01359.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09650917"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMSR1405012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497324"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/PETR.14690"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/JIA2.26148\/FULL"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17290376.2012.745696"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.AJKD.2019.05.031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010014\u20101077\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441317"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319\u20102442.160224"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00467\u2010008\u20101022\u20108"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.003"},{"key":"e_1_2_10_27_1","unstructured":"Department of Statistics South Africa Republic of SA \u201cThe Young and the Restless\u2014Adolescent Health in SA \u201d(2022) Statistics South Africa https:\/\/www.statssa.gov.za."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v10.i4.59"},{"issue":"3","key":"e_1_2_10_29_1","first-page":"132","article-title":"Chronic Renal Failure at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria","volume":"6","author":"Alebiosu C. 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