{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:48:08Z","timestamp":1761536888374,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the relationship between children with multicystic dysplastic kidney (MCDK) that persists or spontaneously regresses over time and local renin\u2013angiotensin\u2013aldosterone system (RAAS) activity in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre, cross\u2010sectional study of patients who were diagnosed with unilateral MCDK or a solitary kidney. The controls were age\u2010 and sex\u2010matched children who underwent evaluation for short stature without any clinical kidney symptoms. We evaluated urinary angiotensinogen (AGT) as a biomarker of local RAAS activity, which acts specifically within the kidneys and differs from systemic RAAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 52 children who were divided into the following four groups: 11 children with residual MCDK (MCDK persisted), 11 with regressed MCDK (MCDK spontaneously regressed), 12 with a solitary kidney and 18 were controls. Hypertension was identified in six patients, all of whom were in the residual or regressed MCDK groups. The urinary AGT\/creatinine ratio was significantly higher in children in the residual MCDK group than in those in the regressed MCDK, solitary and control groups (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01\n                      <jats:italic>,<\/jats:italic>\n                      respectively). A logistic regression model showed that the only significant independent factor for regression of MCDK was urinary AGT\/creatinine (odds ratio: 16.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that local RAAS activation could be associated with persistence of MCDK, but causality cannot be inferred because of the cross\u2010sectional study design. Whether RAAS activation in residual MCDK is involved in the pathogenesis of MCDK or AGT is secreted from the MCDK kidney itself remains unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70132","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:09:19Z","timestamp":1759223359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Multicystic Dysplastic Kidney and the Local Renin\u2013Angiotensin\u2013Aldosterone System: A Pilot Study of a New Biomarker"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3863-2743","authenticated-orcid":false,"given":"Shingo","family":"Ishimori","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Ishiko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-013X","authenticated-orcid":false,"given":"Junya","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kakogawa Central City Hospital  Kakogawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asahi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Inoki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"China","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumichi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saga University Graduate School of Medicine  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimabukuro","sequence":"additional","affiliation":[{"name":"Department of Child Health and Welfare, Graduate School of Medicine University of the Ryukyus  Ginowan Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-9129","authenticated-orcid":false,"given":"Koichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Child Health and Welfare, Graduate School of Medicine University of the Ryukyus  Ginowan Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40746\u2010019\u201000166\u20103"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010023\u201005899\u2010w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098\u2010020\u201003387\u20109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1623"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(00)80169\u20100"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.59.3.3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00370.2003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2006.023"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000109782.28991.26"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6494.2005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.05.045"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010014\u20100963\u20102"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000078808.70309.c4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040414"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17226"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010013\u20100887\u20101"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080810"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.075333"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2007.07328.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101599837"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010020\u201004535\u20101"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00725"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080872"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn377"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.4.F477"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T03:45:48Z","timestamp":1761536748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/nep.70132"],"URL":"https:\/\/doi.org\/10.1111\/nep.70132","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70132"}}