{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:45:27Z","timestamp":1769427927497,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CGRPG3N0041"],"award-info":[{"award-number":["CGRPG3N0041"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Desmopressin was hypothesised to prevent post\u2010kidney biopsy bleeding; however, its efficacy in reducing bleeding and bleeding\u2010related complications has yet to be systematically examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant studies from online electronic databases up to 15 May 2025 were identified. Randomised controlled trials (RCT) reporting the efficacy of desmopressin for prevention of adult post\u2010kidney bleeding complications were included. A random\u2010effect meta\u2010analysis, trial sequential analysis and Bayesian meta\u2010analysis were conducted. We assessed the certainty of the evidence (CoE) by using the GRADE methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven RCTs comprising 827 participants were included. By analysis of all seven studies, desmopressin shows a trend of reducing all post biopsy bleeding events (risk ratio [RR]\u2009=\u20090.77, 95% CI\u2009=\u20090.37\u20131.59) with very low CoE. In a sensitivity analysis excluding an outlier trial, desmopressin was associated with a lower risk of any bleeding and reduced heterogeneity (RR\u2009=\u20090.56, 95% CI\u2009=\u20090.39\u20130.80;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200956%; moderate CoE). Desmopressin did not reduce post biopsy gross hematuria (RR: 1.00, 95% CI: 0.42\u20132.36), severe bleeding needs blood transfusion (RR\u2009=\u20091.46, 95% CI\u2009=\u20090.66\u20133.23), or invasive intervention (RR\u2009=\u20091.39, 95% CI\u2009=\u20090.38\u20135.09). A Bayesian analysis estimated a 76% posterior probability of any benefit, although the 95% credible interval indicated imprecision. Desmopressin is also associated with an RR of 4.52 (95% CI\u2009=\u20092.05\u20139.94;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.0%) for hyponatremia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Desmopressin may reduce overall bleeding after kidney biopsy; however, low\u2010certainty evidence and imprecise estimates are noted, necessitating further large\u2010scale studies to explore its potential benefit, particularly in high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70164","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:47:25Z","timestamp":1768376845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Desmopressin for Post\u2010Kidney Biopsy Bleeding Complications Prevention: A Systematic Review With Frequentist and Bayesian Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-5956","authenticated-orcid":false,"given":"Jia\u2010Jin","family":"Chen","sequence":"first","affiliation":[{"name":"Kidney Research Center, Department of Nephrology Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-7236","authenticated-orcid":false,"given":"Tao\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology Chansn Hospital  Taoyuan city Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-7395","authenticated-orcid":false,"given":"Pei\u2010Chun","family":"Lai","sequence":"additional","affiliation":[{"name":"Education Center National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang\u2010Hao","family":"Hsu","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Department of Nephrology Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huang\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Department of Nephrology Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Health Policy and Management Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Ta","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Cheng Kung University Hospital College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Department of Nephrology Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002432021"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.02.330"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04710420"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.7.2515"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1595-4"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02155-9"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13004"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.04.019"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13662"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.11"},{"key":"e_1_2_14_14_1","first-page":"228","article-title":"Role of Desmopressin Acetate Before Percutaneous Ultrasound\u2010Guided Kidney Biopsy in Patients With Kidney Dysfunction","volume":"34","author":"Sethi J.","year":"2024","journal-title":"Indian Journal of Nephrology"},{"key":"e_1_2_14_15_1","unstructured":"Team RDC \u201cR: A Language and Environment for Statistical Computing (No Title) \u201d2010."},{"key":"e_1_2_14_16_1","unstructured":"\u201cThe Copenhagen Trial Unit CfCIR the Capital Region Copenhagen University Hospital Trial Sequential Analysis (TSA) [Computer Program] \u201dVersion 0.9.5.10 Beta Edn 2021."},{"key":"e_1_2_14_17_1","unstructured":"D. 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A.","year":"2022","journal-title":"Iranian Journal of Kidney Diseases"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_553_20"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz114"},{"key":"e_1_2_14_27_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nefro.2020.12.021","article-title":"No Effect of Desmopressin Administration Before Kidney Biopsy on the Risk of Major Post\u2010Biopsy Bleeding","volume":"42","author":"Cheong M.","year":"2022","journal-title":"Nefrolog\u00eda"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.05.006"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362455"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T01:25:34Z","timestamp":1769390734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/nep.70164"],"URL":"https:\/\/doi.org\/10.1111\/nep.70164","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70164"}}