{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:26Z","timestamp":1787015846231,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024780","name":"Digital Health CRC","doi-asserted-by":"publisher","award":["DHCRC\u20100073"],"award-info":[{"award-number":["DHCRC\u20100073"]}],"id":[{"id":"10.13039\/501100024780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe 5\u2010year outcomes of chronic kidney disease (CKD) in a large, population\u2010based cohort in Western Australia, including rates of progression, regression, kidney failure and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CKD is a major public health challenge associated with increased morbidity and mortality, yet the natural history of early\u2010stage disease in population settings remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study using linked pathology and hospital data for adults with incident CKD between 2006 and 2022. CKD stage was defined by two estimated glomerular filtration rate (eGFR) values \u2265\u20093 and &lt;\u200912\u2009months apart: mild (45\u201359), moderate (30\u201344) and severe (15\u201329)\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      . Outcomes were assessed over 5\u2009years using a competing risks framework.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 153\u2009527 individuals with incident CKD during the study period (mean age 75.6\u2009years, 52.6% women) 118\u2009248 had mild, 58\u2009323 moderate and 20\u2009322 severe CKD. At 5\u2009years, death occurred in 16.8% (mild), 26.7% (moderate) and 30.5% (severe); kidney failure occurred in 0.6%, 2.5% and 30.0%, respectively. CKD progression was more common than regression in mild (20.1% vs. 11.8%) and moderate (18.9% vs. 14.5%) disease. Albuminuria testing was recorded in &lt;\u200935% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>People with early\u2010stage CKD face substantial risks of progression, kidney failure and death within 5\u2009years. The low rate of albuminuria testing suggests missed opportunities for early identification of high\u2010risk individuals and timely intervention. Enhancing CKD detection and monitoring in primary care may improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70172","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:00:52Z","timestamp":1770789652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Five\u2010Year Outcomes of Chronic Kidney Disease in a Longitudinal Population\u2010Based Cohort in Western Australia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-872X","authenticated-orcid":false,"given":"Elizabeth","family":"Thomas","sequence":"first","affiliation":[{"name":"School of Population Health Curtin University  Perth Australia"},{"name":"Medical School The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-0922","authenticated-orcid":false,"given":"Kevin E. 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