{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:36:00Z","timestamp":1772998560097,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hypovolaemic shock (HS) is an uncommon but life\u2010threatening complication in paediatric nephrotic syndrome (NS), yet current guidelines lack a quantitative admission\u2010time instrument to flag high\u2010risk children. We aimed to develop and internally validate a simple model for early HS using routinely available clinical\u2010laboratory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010centre observational study including 258 children with NS admitted to a tertiary paediatric hospital. HS within 24\u2010h of admission was the outcome. Candidate predictors were routine admission variables. Multivariable logistic regression was used to derive a parsimonious model, which was presented as a nomogram. Internal validation and clinical utility were assessed using cross\u2010validation and decision\u2010curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HS occurred in 37\/258 (14.3%). The final 4\u2010variable model retained age, haematocrit, serum albumin and serum sodium. Two markers remained strongly and independently associated with HS: serum albumin, OR\u2009=\u20092.17 per 1\u2009g\/L decrease (95% CI 1.68\u20133.07;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); and serum sodium, OR\u2009=\u20095.79 per 5\u2009mmol\/L decrease (95% CI 1.86\u201322.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Age (OR 0.90 per year) and haematocrit (OR 1.47 per +5%) modestly improved discrimination. Apparent discrimination was excellent (AUC\u2009=\u20090.966; 95% CI 0.945\u20130.988; Brier 0.049) and remained high on cross\u2010validation (AUC\u2009=\u20090.959; 95% CI 0.934\u20130.983; Brier 0.055). DCA showed a higher net benefit of the model than \u2018treat all\u2019 or \u2018treat none\u2019 between 20% and 50% risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A four\u2010variable admission nomogram can stratify early HS risk in children with NS using routine data. External multicentre validation remains necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70173","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:38:26Z","timestamp":1770622706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nomogram\u2010Based Admission Model to Predict Early Hypovolaemic Shock in Paediatric Nephrotic Syndrome: Derivation and Internal Validation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8800-4725","authenticated-orcid":false,"given":"Ngo C.","family":"Quang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-1966","authenticated-orcid":false,"given":"Tran D.","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Nursing and Medical Technology Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen T. B.","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Nephrology Can Tho Children's Hospital  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le H.","family":"My","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0435-4688","authenticated-orcid":false,"given":"Huynh T.","family":"Trung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong T. K.","family":"Loan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truong M. A.","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran H. M.","family":"Duc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.41289"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gloepi.2021.100061"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-022-05739-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1653-4"},{"key":"e_1_2_11_7_1","article-title":"Pathophysiology, Evaluation and Management of Edema in Childhood Nephrotic Syndrome","volume":"3","author":"Ellis D.","year":"2015","journal-title":"Frontiers in Pediatrics"},{"key":"e_1_2_11_8_1","first-page":"43","article-title":"Childhood Nephrotic Syndrome in Uyo: Challenges of Management in a Resource\u2010Limited Setting","volume":"4","author":"Ikpeme E.","year":"2017","journal-title":"World Journal of Biomedical Research"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.11.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-025-04398-1"},{"issue":"4","key":"e_1_2_11_11_1","article-title":"Machine Learning Nomogram for Predicting Dengue Shock Syndrome in Pediatric Patients With Dengue Fever in Vietnam","volume":"17","author":"Nguyen R. 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G.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000375"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1179\/2046905512Y.0000000017"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01051-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.6.1142"},{"issue":"2","key":"e_1_2_11_23_1","first-page":"204","article-title":"Symptomatic Hyponatremia in Nephrotic Syndrome","volume":"134","author":"Hurley J. K.","year":"1980","journal-title":"American Journal of Diseases of Children"},{"issue":"2","key":"e_1_2_11_24_1","first-page":"123","article-title":"Hyponatremia and Elevated Hematocrit in Nephrotic Syndrome","volume":"44","author":"Bertrand Y.","year":"1987","journal-title":"Archives Fran\u00e7aises de P\u00e9diatrie"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2554"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04118-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819323c6"},{"issue":"7","key":"e_1_2_11_28_1","article-title":"Complications Related to Childhood Idiopathic Nephrotic Syndrome, Its Treatment and the Associated Risks","volume":"15","author":"Karakaya D.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2020.103219"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:52:43Z","timestamp":1772988763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/nep.70173"],"URL":"https:\/\/doi.org\/10.1111\/nep.70173","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70173"}}