{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:36:06Z","timestamp":1772998566723,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To externally validate the International IgA Nephropathy Prediction Tool (IIgANN\u2010PT) in a Colombian Hispanic cohort with biopsy\u2010proven IgA nephropathy (IgAN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 397 Colombian Hispanic adults with primary IgAN biopsied between 2004 and 2022 and followed through 1 April 2024. The race\u2010unadjusted IIgANN\u2010PT was applied at biopsy to predict the composite outcome of sustained 50% decline in estimated glomerular filtration rate (eGFR) or end\u2010stage kidney disease (ESKD). Model performance was evaluated at the pre\u2010specified 5\u2010year horizon using time\u2010dependent AUC and Harrell's C\u2010statistic for discrimination, inverse\u2010probability\u2010of\u2010censoring\u2010weighted (IPCW) Brier score for overall prediction error and calibration\u2010in\u2010the\u2010large (CITL) plus calibration slope (\u03b2LP) for calibration. Predicted and observed 5\u2010year risks were also compared across the tool's four pre\u2010specified linear predictor risk strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median follow\u2010up of 4.7\u2009years, 132\/397 (33.3%) patients reached the composite outcome. In the complete\u2010case analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009234), discrimination at 5\u2009years was excellent (AUC 0.94 [95% CI 0.89\u20130.97]; Harrell's C 0.88), with low overall prediction error (IPCW Brier score 0.103). Calibration was accurate on average (CITL 0.03), but the calibration slope was &gt;\u20091 (\u03b2LP 1.40), indicating underprediction concentrated at the extremes; the largest underestimation occurred in the very\u2010high\u2010risk stratum (mean predicted ~67% vs. observed ~80%\u201385%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this Colombian Hispanic IgAN cohort, the IIgANN\u2010PT retained excellent 5\u2010year discrimination and good average calibration, but underestimated risk in the highest\u2010risk patients, supporting its use for risk stratification while emphasising the need for calibration assessment (and potential local recalibration) before broader implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70174","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:25:36Z","timestamp":1771478736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["External Validation of the International\n                    <scp>IgA<\/scp>\n                    Nephropathy Prediction Tool in a Colombian Hispanic Cohort: Insights From a Long\u2010Term Follow\u2010Up Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6214","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Rodelo\u2010Ceballos","sequence":"first","affiliation":[{"name":"Nephrology Service San Vicente Fundaci\u00f3n Hospital  Medell\u00edn Colombia"},{"name":"Department of Internal Medicine, Nephrology Section Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia L.","family":"Calder\u00f3n\u2010Puentes","sequence":"additional","affiliation":[{"name":"Nephrology Service San Vicente Fundaci\u00f3n Hospital  Medell\u00edn Colombia"},{"name":"Department of Internal Medicine, Nephrology Section Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-6914","authenticated-orcid":false,"given":"Mauricio","family":"Restrepo\u2010Escobar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rheumatology Section Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1206793"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.024"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268421"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patol.2025.100813"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp273"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy302"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0600"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.05.021"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.046"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.10.033"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S455115"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.07.036"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.03.016"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN111110"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad199"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.07.009"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/ijne\/6974280"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201013\u201033"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.778464"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007748\u2010z"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:52:48Z","timestamp":1772988768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/nep.70174"],"URL":"https:\/\/doi.org\/10.1111\/nep.70174","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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