{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:45:46Z","timestamp":1776048346268,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"publisher","award":["MMH\u2010114\u201032"],"award-info":[{"award-number":["MMH\u2010114\u201032"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) remains a major global health concern. Current treatments primarily delay disease progression and alleviate complications rather than targeting key mechanisms. This pilot study aimed to evaluate the antifibrotic and anti\u2010inflammatory effects of Sebivo on kidney and heart tissues in a rat CKD model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 30 male Sprague\u2013Dawley rats were randomly assigned to sham\u2010operated control, CKD and CKD\u2009+\u2009Sebivo groups. CKD was induced by 5\/6 nephrectomy and rats received no treatment, saline or Sebivo for 12\u2009weeks after surgery. Serum levels of total and free\n                      <jats:italic>p<\/jats:italic>\n                      \u2010cresyl sulphate (PCS), indoxyl sulphate (IS) levels, as well as creatinine and blood urea nitrogen (BUN) were measured at 8 and 12\u2009weeks following administration. After 12\u2009weeks of treatment, kidney and heart fibrosis were evaluated by histological analysis, while inflammatory and fibrotic markers were assessed by qRT\u2010PCR and western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sebivo significantly reduced total serum PCS levels in CKD\u2009+\u2009Sebivo group compared to CKD group at 12\u2009weeks (4.17\u2009\u00b1\u20090.99 vs. 8.78\u2009\u00b1\u20090.01\u2009\u03bcg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Heart fibrosis was significantly reduced in CKD\u2009+\u2009Sebivo group compared to CKD group (22.44%\u2009\u00b1\u20096.82% vs. 34.90%\u2009\u00b1\u20091.47%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with a similar trend observed in the kidney. Sebivo improved renal function as indicated by decreased BUN and creatinine levels. Additionally, TGF\u2010\u03b21 mRNA and the protein levels of IL\u20106, TGF\u2010\u03b21, TIMP\u20101 and COL1A1 were significantly decreased in the kidney following Sebivo treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sebivo demonstrated potential to improve renal fibrosis and function, likely through modulating fibrotic and inflammatory pathways, suggesting Sebivo as a novel therapeutic treatment for CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70182","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:15:13Z","timestamp":1773137713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sebivo Ameliorated Fibrotic and Inflammatory Changes in Kidney and Heart in Animal Model of Chronic Kidney Disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Cheng\u2010Jui","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chith\u2010Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastrointestionalogy, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chith\u2010Jen","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8254-3604","authenticated-orcid":false,"given":"Horng\u2010Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastrointestionalogy, Department of Internal Medicine Mackay Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0248-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.05.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.092775"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.026"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.08.021"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.031"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.043"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v4.i1.57"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq580"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.12.016"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.01.015"},{"key":"e_1_2_12_16_1","unstructured":"C.\u2010J. 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