{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T02:45:40Z","timestamp":1776048340961,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","award":["RSS_2024_072"],"award-info":[{"award-number":["RSS_2024_072"]}],"id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to characterise hand tremor and examine its relationship with tacrolimus administration time and systemic exposure in adult kidney transplant recipients early post\u2010transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Quantitative and qualitative data on hand tremor were collected from patients receiving immediate\u2010release tacrolimus, approximately 1\u2009month post\u2010transplantation. Smartphone accelerometry was used to objectively assess tremor pre\u2010 and 2\u2009h post\u2010tacrolimus administration and values were compared using a Wilcoxon signed\u2010rank test. A Welch's analysis of variance (ANOVA) was used to determine if tacrolimus trough concentration (\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ), 2\u2009h post\u2010dose concentration (\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      ) and the ratio of\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      \/\n                      <jats:italic>C<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      were significantly different between patients reporting no, mild or moderate\/severe tremor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and seven patients enrolled in the study. Eighty percent of patients reported hand tremor, often during voluntary hand movement. Thirty\u2010eight percent said it interfered with daily activities, impeding their ability to perform basic daily tasks required for eating, drinking, accessing medicines and working. Hand tremor was not more severe at 2\u2009h post\u2010tacrolimus intake. Tacrolimus exposure was not associated with patient\u2010reported tremor severity. Significantly greater amplitude and power in hand movement were detectable by smartphone accelerometry in patients reporting hand tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hand tremor is highly prevalent early post\u2010transplantation and has a major impact on patient functionality and quality of life. Further research is needed to develop novel tacrolimus exposure estimates that better correlate with tremor, and to identify improved ways to clinically assess, manage and mitigate the impact of hand tremor following transplantation. Smartphone accelerometry may be a useful tool in assessing tremor in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70187","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:24:47Z","timestamp":1773156287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterising Hand Tremor in Adult Kidney Transplant Recipients: Its Impact on Daily Activities and Relationship With Tacrolimus Administration and Exposure"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9991-7284","authenticated-orcid":false,"given":"Catherine P.","family":"King","sequence":"first","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-6657","authenticated-orcid":false,"given":"Amelia R.","family":"Cossart","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-7179","authenticated-orcid":false,"given":"Nicole M.","family":"Isbel","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-2151","authenticated-orcid":false,"given":"Scott B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-2632","authenticated-orcid":false,"given":"Meng\u2010Wong","family":"Taing","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana R.","family":"Leary","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent T.","family":"Houlihan","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-9376","authenticated-orcid":false,"given":"Christine E.","family":"Staatz","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13206"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.27475"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.10951"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8904-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12581"},{"key":"e_1_2_10_8_1","article-title":"Tacrolimus Versus Cyclosporin as Primary Immunosuppression for Kidney Transplant Recipients","volume":"4","author":"Webster A. 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