{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:50:01Z","timestamp":1776905401823,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Post\u2010renal transplant anaemia significantly impacts patient outcomes and quality of life. The only option available until recently was erythropoietin (EPO) that requires intravenous or subcutaneous injection. New class of drugs that are hypoxia\u2010inducible factor prolyl hydroxylase inhibitor (HIF\u2010PHI) (desidustat) have become available and there is scarce data on their use in kidney transplant recipients (KTRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective observational study which included 58 renal transplant recipients with anaemia (Hb\u2009&lt;\u200910\u2009g\/dL) who were started on either oral HIF\u2010PHI in the form of desidustat (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) or EPO (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) based on nephrologist discretion. Adult KTRs with a haemoglobin (Hb) level of less than 10\u2009g\/dL were included. Patients with acute graft dysfunction, bleeding and primary haematological diseases were excluded. Baseline clinical characteristics were recorded. Primary outcomes were change in Hb at 8\u2009weeks in the two groups. Secondary outcomes included inflammatory markers (CRP, ESR), iron indices and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both desidustat and erythropoietin groups showed significant improvement in Hb from baseline to 2\u2009months (desidustat: 8.69\u2009\u00b1\u20090.86 to 9.89\u2009\u00b1\u20090.92\u2009g\/dL; EPO: 8.54\u2009\u00b1\u20090.73 to 9.55\u2009\u00b1\u20090.71\u2009g\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). No significant differences were observed in inflammatory markers or iron indices. Both treatments were well\u2010tolerated, with no reported adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with desidustat resulted in improvement in haemoglobin levels with acceptable tolerability over short\u2010term follow\u2010up similar to erythropoietin. The convenience of oral administration supports its potential role as a patient\u2010centred option for anaemia management following kidney transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70201","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:36:02Z","timestamp":1775565362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Desidustat Versus Erythropoietin in Post Kidney Transplant Anaemia: A Prospective Observational Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Pooja","family":"Barak","sequence":"first","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-6133","authenticated-orcid":false,"given":"Smita","family":"Divyaveer","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Pattanaik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Kharbanda","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna Ethiraj","family":"S.","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh","family":"Subramani","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushal","family":"Kekan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simran","family":"Behl","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepy","family":"Zohmangaihi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-9426","authenticated-orcid":false,"given":"Nabhajit","family":"Mallik","sequence":"additional","affiliation":[{"name":"Department of Hematology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3754-7774","authenticated-orcid":false,"given":"Deepesh","family":"Lad","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-4148","authenticated-orcid":false,"given":"Madhumita","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Hepatology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maninder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-8642","authenticated-orcid":false,"given":"Urmila","family":"Anandh","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amrita Institute of Medical Sciences and Research Centre  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harbir Singh","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of 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