{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:49:56Z","timestamp":1776905396763,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2005000"],"award-info":[{"award-number":["2020YFC2005000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502500"],"award-info":[{"award-number":["2022YFC2502500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502502"],"award-info":[{"award-number":["2022YFC2502502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130021"],"award-info":[{"award-number":["82130021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is a serious complication in older patients. A practical prediction model may aid in identifying high\u2010risk patients for early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included hospitalized patients aged \u2265\u200965\u2009years (2018\u20132020) with available serum creatinine (Scr). Data from 2018 to 2019 were used for model development, and data from 2020 were used for validation. The primary outcome was hospital\u2010acquired AKI. A multivariable logistic regression model was built using baseline, latest, and trend\u2010based variables. Four models were constructed using the least absolute shrinkage and selection operator (LASSO) and stepwise selection, and the Senior Hospitalized Adults' AKI Risk Prediction (SHARP) score was derived as a simplified scoring system. Performance was evaluated using the area under the receiver\u2010operating characteristic curve (AUC), calibration curves, and the Hosmer\u2010Lemeshow test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 14\u2009576 derivation and 7328 validation admissions, AKI incidence was 6.2% and 5.3%, respectively. The model incorporated eight risk factors: heart failure, chronic kidney disease, baseline prealbumin, baseline Scr, highest B\u2010type natriuretic peptide, highest blood urea nitrogen, highest C\u2010reactive protein, latest heart rate. It showed strong discrimination (AUC: 0.86\u20130.87) and good calibration (Hosmer\u2010Lemeshow\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The simplified SHARP score maintained excellent performance, effectively stratifying AKI risk. In the validation cohort, the SHARP score predicted AKI with a median lead time of 40.73, 38.64, and 24.05\u2009h for low, moderate, and high\u2010risk groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SHARP score allows clinicians to quickly assess the risk of AKI in older hospitalized patients. Future studies should focus on external validation to confirm its predictive accuracy and generalizability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70204","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:39:44Z","timestamp":1775785184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Senior Hospitalized Adults' Risk Prediction Score for Acute Kidney Injury: Derivation and External Validation From an Observational Cohort"],"prefix":"10.1111","volume":"31","author":[{"given":"Youlu","family":"Zhao","sequence":"first","affiliation":[{"name":"Renal Division Peking University First Hospital  Beijing China"},{"name":"Institute of Nephrology, Peking University  Beijing China"},{"name":"NHC Key Laboratory of Renal Disease (Peking University)  Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China  Beijing China"},{"name":"Beijing Key Laboratory of Precision Medicine and New\u2010Drug\/Equipment Development for Severe Kidney Disease  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division Peking University First Hospital  Beijing China"},{"name":"Institute of Nephrology, Peking University  Beijing China"},{"name":"NHC Key Laboratory of Renal Disease (Peking University)  Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China  Beijing China"},{"name":"Beijing Key Laboratory of Precision Medicine and New\u2010Drug\/Equipment Development for Severe Kidney Disease  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damin","family":"Xu","sequence":"additional","affiliation":[{"name":"Renal Division Peking University First Hospital  Beijing China"},{"name":"Institute of Nephrology, Peking University  Beijing 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