{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:49:57Z","timestamp":1776905397927,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In patients with chronic kidney disease (CKD), the burden of atherosclerotic cardiovascular disease (ASCVD) remains distinctively high. Management of dyslipidaemia in individuals with CKD is essential yet often deficient due to polypharmacy, poor adherence, and statin intolerance. Inclisiran, a small interfering RNA (siRNA) that targets hepatic proprotein convertase subtilisin\/kexin type 9 (PCSK9) synthesis, offers an innovative, long\u2010acting approach to lower LDL\u2010cholesterol. This manuscript presents evidence\u2010based recommendations based on available clinical trial evidence and collective specialist opinion. We propose a practical stratification tool (Inclisiran Suitability Stratification Tool for CKD) and treatment algorithm, comparing Inclisiran with other lipid\u2010lowering agents to support individualized clinical decision\u2010making.<\/jats:p>","DOI":"10.1111\/nep.70206","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:40:15Z","timestamp":1776498015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence\u2010Based Recommendations on the Use of Inclisiran in Patients With Chronic Kidney Disease"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-5131","authenticated-orcid":false,"given":"Sourabh","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Nephrology Vardhman Mahavir Medical College &amp; Safdarjung Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-121X","authenticated-orcid":false,"given":"Sanjay","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Bharti Hospital  Karnal India"},{"name":"University Centre for Research &amp; Development Chandigarh University  Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Sahay","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osmania Medical College  Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College  Vellore India"},{"name":"Non Communicable Disease Unit Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Nagendra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, JSS Medical College JSS Academy of Higher Education and Research  Mysore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Nephrology Vardhman Mahavir Medical College &amp; Safdarjung Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-9553","authenticated-orcid":false,"given":"Neha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology Vardhman Mahavir Medical College &amp; Safdarjung Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhur","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine All India Institute of Medical Sciences  Bathinda Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9409-3874","authenticated-orcid":false,"given":"Sree Bhushan","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nizams Institute of Medical Sciences  Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney C. W.","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021060747"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60595-4"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy174"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874192401105010041"},{"issue":"6","key":"e_1_2_14_6_1","first-page":"631","article-title":"Statin Therapy: Review of Safety and Potential Side Effects","volume":"32","author":"Ramkumar S.","year":"2016","journal-title":"Acta Cardiologica Sinica"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2021.1915799"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2025.101019"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0613-0"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S338424"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-023-00568-7"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-025-02158-0"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.08.021"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.11.010"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912387"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2022-0133"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043545"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810177"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60739-3"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13638-0"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.12.1585"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2025.103897"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11104"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2024.7.n2679"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00712-8"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa077"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8129513"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-021-00477-7"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1449712"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2022.100138"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-022-01152-8"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:07:53Z","timestamp":1776902873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/nep.70206"],"URL":"https:\/\/doi.org\/10.1111\/nep.70206","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70206"}}