{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:04:37Z","timestamp":1779681877260,"version":"3.53.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K13590"],"award-info":[{"award-number":["25K13590"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Elevated resting heart rate has been associated with increased risks of all\u2010cause mortality and cardiovascular events. However, its association with the development of chronic kidney disease (CKD) among individuals with established CKD risk factors under clinical care remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 1210 participants with one or more CKD risk factors, an estimated glomerular filtration rate (eGFR)\u2009\u2265\u200960\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , and no proteinuria at baseline, enrolled in the Fukushima Cohort Study, to evaluate the association between baseline resting heart rate and new\u2010onset CKD. Participants were classified into three groups according to baseline heart rate: &lt;\u200970 (reference), 70\u201379 and \u2265\u200980\u2009bpm. Associations were examined using Cox proportional hazards models adjusted for demographic, clinical and treatment covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a mean follow\u2010up of 4.3\u2009years, 353 participants developed CKD. Compared with the reference group (&lt;\u200970\u2009bpm), the adjusted hazard ratios for CKD were 0.94 (95% confidence interval, 0.71\u20131.25) in the 70\u201379\u2009bpm group and 1.35 (95% confidence interval, 1.04\u20131.74) in the \u2265\u200980\u2009bpm group. Subgroup analysis showed that the association between resting heart rate and new\u2010onset CKD was stronger among participants with diabetes than among those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among individuals with CKD risk factors but without CKD at baseline, a higher resting heart rate was associated with an increased risk of incident CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70223","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:16:38Z","timestamp":1779336998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resting Heart Rate and Incident\n                    <scp>CKD<\/scp>\n                    Among Individuals With\n                    <scp>CKD<\/scp>\n                    Risk Factors"],"prefix":"10.1111","volume":"31","author":[{"given":"Hirotaka","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-9355","authenticated-orcid":false,"given":"Kenichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Fukushima Medical University  Fukushima Japan"},{"name":"Division of Advanced Community Based Care for Lifestyle Related Diseases Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Fukushima Medical University  Fukushima Japan"},{"name":"Division of Advanced Community Based Care for Lifestyle Related Diseases Fukushima Medical University  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