{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:04:23Z","timestamp":1779681863550,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The supply of donor kidneys (living and deceased) has fallen far behind the need, while the number of patients with end stage kidney disease continues to rise, increasing their risk of cardiovascular mortality. Kidney transplant candidates frequently exhibit large artery calcification, a major contributor to cardiovascular death. This study aimed to evaluate the relationship between abdominal arterial calcification (AAC) and survival in patients awaiting kidney transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We modified the coronary calcium scoring method (Modified Agatston Method) and applied it to quantify AAC. This retrospective study included all adult patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094184) listed for kidney transplant from 2005 to 2023 who had undergone abdominal computed tomography (CT) scans. Patients were categorised into two groups: those who died while on the waiting list (DWL) and those who survived (SWL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 4184 candidates, 446 (10.7%) died while on the waiting list, and 3738 (89.3%) survived to transplant or study end. Patients in the DWL group had significantly higher AAC scores across all vascular sites. The median total AAC score was 3605.8 (IQR 780.1\u20139017.3) in the DWL group versus 940.1 (IQR 49.2\u20134915.0) in the SWL group. Each 1000\u2010point increase in total AAC was associated with a 5.1% increase in mortality risk (HR 1.051;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). An AAC cutoff of &gt;\u20091769 correlated with reduced 5\u2010year survival (45.4% vs. 77.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AAC scoring on non\u2010contrast abdominal CT represents a noninvasive biomarker of mortality in kidney transplant waitlist patients and may enhance risk stratification and personalised care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70227","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:36:29Z","timestamp":1779435389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abdominal Arterial Calcification as an Imaging Biomarker of Mortality in Kidney Transplant Waitlist Patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3958-218X","authenticated-orcid":false,"given":"Wassim","family":"Toomah","sequence":"first","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-2544","authenticated-orcid":false,"given":"Roaa","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amro","family":"Idilbi","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Hanouneh","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Alhassoun","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Hussam","family":"Hallak","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Saria","family":"Aldarwish","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Amir","family":"Balloura","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren F.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Alasfar","sequence":"additional","affiliation":[{"name":"Transplant Center, Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Stegall","sequence":"additional","affiliation":[{"name":"Transplant Center, Mayo Clinic Minnesota  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Schinstock","sequence":"additional","affiliation":[{"name":"Transplant Center, Mayo Clinic Minnesota  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-0470","authenticated-orcid":false,"given":"Tambi","family":"Jarmi","sequence":"additional","affiliation":[{"name":"Department of Transplant Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-019-00634-x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.85gr.18001"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504546"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002951"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.00094.x"},{"issue":"8","key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/TP.0000000000001770","article-title":"KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors","volume":"101","author":"Lentine K. L.","year":"2017","journal-title":"Transplantation"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13173"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.219"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9857-x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0363"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.027"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy217"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.02.005"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017205"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023037"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.727"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad083"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02525.x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0314776"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320919895"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2158869"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-015-0260-7"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12581"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502328"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328331b81e"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092893"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy158"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42155-025-00542-1"},{"issue":"1","key":"e_1_2_14_31_1","first-page":"397","article-title":"Quantitative Abdominal Arterial Calcification Correlates With Kidney Transplant Waitlist Mortality","volume":"49","author":"Jarmi T.","year":"2024","journal-title":"Kidney and Blood Pressure Research"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2022.09.002"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T03:28:29Z","timestamp":1779679709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/nep.70227"],"URL":"https:\/\/doi.org\/10.1111\/nep.70227","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70227"}}