{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T01:25:33Z","timestamp":1787189133826,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Haematuria is frequently present in podocytopathies, but its significance and prognostic value are not well described. This study aimed to determine the prevalence and association between persistent haematuria and kidney survival in patients with membranous nephropathy (MN), minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 236 adults with biopsy\u2010proven primary podocytopathies. Persistent haematuria was defined as \u2265\u20095 red blood cells per high\u2010power field in \u2265\u20093 consecutive urine specimens within 3\u2009months post\u2010biopsy. The primary outcome was end\u2010stage kidney disease (ESKD) requiring chronic renal replacement therapy. Kaplan\u2013Meier analysis and Cox proportional hazards regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 236 participants (114 MN, 76 MCD, 46 FSGS), 73 (31%) had persistent haematuria. Participants with haematuria had higher proteinuria (5.3 vs. 3.2\u2009g\/g,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and were more likely to have hypertension (55% vs. 36%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). During a median follow\u2010up of 96\u2009months, 38 patients (16%) reached ESKD. ESKD incidence was significantly higher in patients with persistent haematuria (32% vs. 9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After adjusting for diagnosis, eGFR, proteinuria, Charlson comorbidity score and histological chronicity score, persistent haematuria remained independently associated with ESKD (hazard ratio: 3.55; 95% CI: 1.78\u20137.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent haematuria is prevalent among patients with podocytopathies and is significantly and independently associated with ESKD. Urinalysis, including microscopic haematuria assessment, is widely available and inexpensive, providing a valuable data point to help formulate patient prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.70252","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:51:00Z","timestamp":1785736260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-5874","authenticated-orcid":false,"given":"Gabriel","family":"\u0218tefan","sequence":"first","affiliation":[{"name":"Department of Nephrology University of Medicine and Pharmacy \u2018Carol Davila\u2019  Bucharest Romania"},{"name":"Department of Nephrology \u2018Dr. Carol Davila\u2019 Teaching Hospital of Nephrology  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"Petre","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Medicine and Pharmacy \u2018Carol Davila\u2019  Bucharest Romania"},{"name":"Department of Pathology \u2018Dr. Carol Davila\u2019 Teaching Hospital of Nephrology  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Zugravu","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Medicine and Pharmacy \u2018Carol Davila\u2019  Bucharest Romania"},{"name":"Department of Nephrology \u2018Dr. Carol Davila\u2019 Teaching Hospital of Nephrology  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Stancu","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Medicine and Pharmacy \u2018Carol Davila\u2019  Bucharest Romania"},{"name":"Department of Nephrology \u2018Dr. Carol Davila\u2019 Teaching Hospital of Nephrology  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0951-0"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15242"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000070153.91733.09"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1141"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016101121"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3136-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.11.2192"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.9.1586"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080894"},{"key":"e_1_2_12_12_1","first-page":"426","article-title":"Prediction of Short\u2010 and Long\u2010Term Outcomes in Childhood Nephrotic Syndrome","volume":"5","author":"Carter S. 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