{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:59:46Z","timestamp":1790132386920,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare disorder characterised by the simultaneous or sequential occurrence of acute tubulointerstitial nephritis and uveitis, in the absence of systemic disease. Its true prevalence is likely underestimated, as renal and ocular manifestations may not appear concurrently. We conducted a retrospective case series of patients diagnosed with TINU at a single tertiary centre between 2016 and 2025. Clinical, biochemical, histopathological and ophthalmological data were reviewed. Long\u2010term renal and ocular outcomes were assessed. Ten patients (female:male 6:4) were identified, with a median age at diagnosis of 41\u2009years (range 15\u201367). Renal disease preceded uveitis in 60% of cases, with a mean interval of 5.6\u2009months. At presentation, 70% had serum creatinine &gt;\u2009200\u2009\u03bcmol\/L and one patient required transient dialysis. All renal biopsies demonstrated tubulointerstitial nephritis with preserved glomeruli. All patients were treated with systemic corticosteroids, with topical therapy for uveitis. Renal relapse occurred in 60% of patients, often during steroid tapering, and required prolonged corticosteroid therapy or mycophenolate mofetil. At final follow\u2010up (median 44\u2009months), 50% had chronic kidney disease (eGFR\u2009&lt;\u200960\u2009mL\/min). Relapsing disease was more frequent in females and patients under 18\u2009years. At last follow\u2010up, mean serum creatinine was 89\u2009\u03bcmol\/L, with 50% of patients having CKD G3a. Ophthalmologic data (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) showed bilateral anterior uveitis in all cases, with intermediate involvement in three. Two developed steroid\u2010induced intraocular hypertension. Ocular relapse occurred in six patients and frequently paralleled renal disease activity. We herein report one of the longest median follow\u2010up durations (44\u2009months) among biopsy\u2010proven cohorts of interstitial nephritis. Our cohort spans a broader age range (15\u201367\u2009years) than traditionally described with an adult predominance. Despite a 60% relapse rate, response to steroids and immunosuppression was good. Proteinuria at presentation was noted in individuals who developed subsequent CKD supporting the need for follow up and proteinuria management where relevant.\n                  <\/jats:p>","DOI":"10.1111\/nep.70271","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:36:02Z","timestamp":1787870162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tubulointerstitial Nephritis With Uveitis (\n                    <scp>TINU<\/scp>\n                    ) Syndrome: A Case Series and Review of Literature"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3510-3085","authenticated-orcid":false,"given":"Weaam","family":"Ali","sequence":"first","affiliation":[{"name":"Nephrology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Nephrology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-4085","authenticated-orcid":false,"given":"Smeeta","family":"Sinha","sequence":"additional","affiliation":[{"name":"Nephrology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Donal O'Donoghue Renal Research Centre Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine &amp; Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-2247","authenticated-orcid":false,"given":"Dimitrios","family":"Poulikakos","sequence":"additional","affiliation":[{"name":"Nephrology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Donal O'Donoghue Renal Research Centre Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine &amp; Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Histopathology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-5558","authenticated-orcid":false,"given":"Constantina","family":"Chrysochou","sequence":"additional","affiliation":[{"name":"Nephrology Department, Salford Royal Hospital Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Donal O'Donoghue Renal Research Centre Northern Care Alliance  Salford Greater Manchester UK"},{"name":"Division of Cardiovascular Sciences, Faculty of Biology, Medicine &amp; Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.01.044"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0677-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90390-3"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"189","article-title":"Tubulointerstitial Nephritis and Uveitis Syndrome","volume":"9","author":"Mandeville J. T.","year":"2001","journal-title":"Ocular Immunology and Inflammation"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"471","article-title":"Tubulointerstitial Nephritis and Uveitis Syndrome: A Systematic Review","volume":"37","author":"Regusci A.","year":"2022","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1443"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0069-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00795-9"},{"key":"e_1_2_11_10_1","first-page":"485","article-title":"Tubulointerstitial Nephritis With Uveitis Syndrome Following Varicella Zoster Reactivation","volume":"71","author":"Ljutiac D.","year":"1995","journal-title":"Nephron"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01646656"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2010.483313"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.194.71"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00856521"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0879-x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0376"},{"issue":"4","key":"e_1_2_11_17_1","first-page":"1063","article-title":"Tubulointerstitial Nephritis and Uveitis in Children During the COVID\u201019 Pandemic: Report of Four Cases","volume":"38","author":"Sakhinia F.","year":"2023","journal-title":"Pediatric Nephrology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.09.013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09051209"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.70271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.70271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:03:55Z","timestamp":1790129035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.70271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/nep.70271"],"URL":"https:\/\/doi.org\/10.1111\/nep.70271","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70271"}}