{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:59:39Z","timestamp":1790132379265,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fibronectin glomerulopathy (FNG) is a rare renal disorder characterized by excessive glomerular fibronectin deposition, often associated with variants in the fibronectin 1 (\n                    <jats:italic>FN1<\/jats:italic>\n                    ) gene. Clinically, FNG presents with proteinuria, hematuria, and hypertension, and may progress to end\u2010stage kidney disease. However, its long\u2010term clinical course and optimal management remain incompletely defined. We report a sporadic case of FNG in a 26\u2010year\u2010old woman carrying an\n                    <jats:italic>FN1<\/jats:italic>\n                    variant, c.2918A &gt; G (NM_212482.4). Seventeen years after initial detection of proteinuria, she developed nephrotic syndrome with generalized edema. Supportive therapy, including renin\u2013angiotensin system inhibitors and diuretics, was insufficient, and prednisolone and cyclosporine A were initiated for management of nephrotic syndrome. The patient subsequently achieved partial remission, with urinary protein decreasing to &lt;\u20091\u2009g\/gCr and no major adverse events. During tapering of immunosuppression, a sodium\u2013glucose cotransporter 2 (SGLT2) inhibitor was added as adjunct therapy. This case suggests a potential role for immunosuppressive therapy in management of late\u2010onset nephrotic syndrome associated with FNG, with SGLT2 inhibition potentially contributing to maintenance of remission.\n                  <\/jats:p>","DOI":"10.1111\/nep.70273","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:28:01Z","timestamp":1788233281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Control of Late\u2010Onset Nephrotic Syndrome in\n                    <scp>\n                      <i>FN1<\/i>\n                    <\/scp>\n                    \u2010Associated Fibronectin Glomerulopathy: A 17\u2010Year Clinical Course"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-8027","authenticated-orcid":false,"given":"Nobuhiro","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Department of Nephrology 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