{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:37:22Z","timestamp":1773052642974,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001825","name":"Styrelsen for Forskning og Innovation","doi-asserted-by":"publisher","award":["j. no. 59677"],"award-info":[{"award-number":["j. no. 59677"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"crossref","award":["j. no. 171-2013-6"],"award-info":[{"award-number":["j. no. 171-2013-6"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["neuromodulationjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromodulation: Technology at the Neural Interface"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1111\/ner.12758","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T08:53:29Z","timestamp":1518598409000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["An Intraneural Electrode for Bioelectronic Medicines for Treatment of Hypertension"],"prefix":"10.1016","volume":"21","author":[{"given":"Cristian","family":"Sevcencu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes J.","family":"Struijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/ner.12758_bib1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrd4351","article-title":"Bioelectronic medicines: a research roadmap","volume":"13","author":"Birmingham","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1111\/ner.12758_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/496159a","article-title":"Drug discovery: a jump-start for electroceuticals","volume":"496","author":"Famm","year":"2013","journal-title":"Nature"},{"key":"10.1111\/ner.12758_bib3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1161\/CIRCRESAHA.116.303603","article-title":"New approaches in the treatment of hypertension","volume":"116","author":"Oparil","year":"2015","journal-title":"Circ Res"},{"key":"10.1111\/ner.12758_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00004691-200109000-00005","article-title":"Vagus nerve stimulation, side effects, and long-term safety","volume":"18","author":"Ben-Menachem","year":"2001","journal-title":"J Clin Neurophysiol"},{"key":"10.1111\/ner.12758_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/01.HYP.26.2.341","article-title":"Structural versus functional modulation of the arterial baroreflex","volume":"26","author":"Chapleau","year":"1995","journal-title":"Hypertension"},{"key":"10.1111\/ner.12758_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ar.1091590107","article-title":"The myelinated fibers in the aortic nerve of the swine","volume":"159","author":"Schmidt","year":"1967","journal-title":"Anat Rec"},{"key":"10.1111\/ner.12758_bib7","doi-asserted-by":"crossref","first-page":"036011","DOI":"10.1088\/1741-2560\/11\/3\/036011","article-title":"Blood pressure control with selective vagal nerve stimulation and minimal side effects","volume":"11","author":"Plachta","year":"2014","journal-title":"J Neural Eng"},{"key":"10.1111\/ner.12758_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/hr.2015.122","article-title":"Effect of selective vagal nerve stimulation on blood pressure, heart rate and respiratory rate in rats under metoprolol medication","volume":"39","author":"Gierthmuehlen","year":"2016","journal-title":"Hypertens Res"},{"key":"10.1111\/ner.12758_bib9","series-title":"Converging clinical and engineering research on neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016), October 18\u201321, 2016","first-page":"995","article-title":"Stimulation waveforms for the selective activation of baroreceptor nerve fibers in the cervical vagus nerve","author":"Nielsen","year":"2017"},{"key":"10.1111\/ner.12758_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bios.2017.06.031","article-title":"A neural blood pressure marker for bioelectronic medicines for treatment of hypertension","volume":"98","author":"Sevcencu","year":"2017","journal-title":"Biosens Bioelectron"},{"key":"10.1111\/ner.12758_bib11","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/01.CIR.83.5.1557","article-title":"Short-term effect of dynamic exercise on arterial blood pressure","volume":"83","author":"Pescatello","year":"1991","journal-title":"Circulation"},{"key":"10.1111\/ner.12758_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0034-5687(00)00202-4","article-title":"An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors","volume":"125","author":"Schelegle","year":"2001","journal-title":"Respir Physiol"},{"key":"10.1111\/ner.12758_bib13","doi-asserted-by":"crossref","unstructured":"Sevcencu C, Nielsen TN, Kjaergaard B, Struijk JJ. A respiratory marker derived from left vagus nerve signals recorded with implantable cuff electrodes. Neuromodulation 2017; e-pub ahead of print. doi: 10.1111\/ner.12630.","DOI":"10.1111\/ner.12630"},{"key":"10.1111\/ner.12758_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/ANA.0b013e31815b7df1","article-title":"Vagus nerve stimulation therapy for seizures","volume":"20","author":"Ramani","year":"2008","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1111\/ner.12758_bib15","doi-asserted-by":"crossref","first-page":"026003","DOI":"10.1088\/1741-2560\/10\/2\/026003","article-title":"High-resolution measurement of electrically-evoked vagus nerve activity in the anesthetized dog","volume":"10","author":"Yoo","year":"2013","journal-title":"J Neural Eng"},{"key":"10.1111\/ner.12758_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2017.06.036","article-title":"Long-term vagal stimulation for heart failure: eighteen month results from the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) trial","volume":"244","author":"De Ferrari","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1111\/ner.12758_bib17","first-page":"3416","article-title":"Detection of baroreceptor activity in rat vagal nerve recording using a multi-channel cuff-electrode and real-time coherent averaging","volume":"2012","author":"Plachta","year":"2012","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1111\/ner.12758_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1109\/TNSRE.2004.831491","article-title":"Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodes","volume":"12","author":"Lawrence","year":"2004","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"10.1111\/ner.12758_bib19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1109\/TNSRE.2005.856072","article-title":"Direct neural sensory feedback and control of a prosthetic arm","volume":"13","author":"Dhillon","year":"2005","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"10.1111\/ner.12758_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1109\/TNSRE.2013.2267936","article-title":"Stimulation selectivity of the \u201cthin-film longitudinal intrafascicular electrode\u201d (tfLIFE) and the \u201ctransverse intrafascicular multi-channel electrode\u201d (TIME) in the large nerve animal model","volume":"22","author":"Kundu","year":"2014","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"10.1111\/ner.12758_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1109\/TBME.2011.2169671","article-title":"Fascicle-selectivity of an intraneural stimulation electrode in the rabbit sciatic nerve","volume":"59","author":"Nielsen","year":"2012","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1111\/ner.12758_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1109\/TNSRE.2013.2278479","article-title":"Comparison of mono-, bi-, and tripolar configurations for stimulation and recording with an interfascicular interface","volume":"22","author":"Nielsen","year":"2014","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"key":"10.1111\/ner.12758_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.1971.sp009419","article-title":"The effects of altering mean pressure, pulse pressure and pulse frequency on the impulse activity in baroreceptor fibres from the aortic arch and right subclavian artery in the rabbit","volume":"214","author":"Angell James","year":"1971","journal-title":"J Physiol"},{"key":"10.1111\/ner.12758_bib24","first-page":"151","article-title":"Re-evaluation of respiratory reflexes","volume":"51","author":"Paintal","year":"1966","journal-title":"Q J Exp Physiol Cogn Med Sci"},{"key":"10.1111\/ner.12758_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physrev.1973.53.1.159","article-title":"Vagal sensory receptors and their reflex effects","volume":"53","author":"Paintal","year":"1973","journal-title":"Physiol Rev"},{"key":"10.1111\/ner.12758_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1113\/jphysiol.1964.sp007479","article-title":"Aortic baroreceptor threshold and sensitivity in rabbits at different ages","volume":"174","author":"Bloor","year":"1964","journal-title":"J Physiol"},{"key":"10.1111\/ner.12758_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0034-5687(74)90009-7","article-title":"Responses of pulmonary stretch receptors to static pressure inflations","volume":"21","author":"Miserocchi","year":"1974","journal-title":"Respir Physiol"},{"key":"10.1111\/ner.12758_bib28","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1152\/ajplegacy.1956.187.3.558","article-title":"Effect of volume and rate of inflation and deflation on transpulmonary pressure and response of pulmonary stretch receptors","volume":"187","author":"Davis","year":"1956","journal-title":"Am J Physiol"},{"key":"10.1111\/ner.12758_bib29","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1109\/10.790501","article-title":"On statistical properties of whole nerve cuff recordings","volume":"46","author":"Jezernik","year":"1999","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1111\/ner.12758_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1113\/expphysiol.2006.033902","article-title":"The influence of heart rate on baroreceptor fibre activity in the carotid sinus and aortic depressor nerves of the rabbit","volume":"91","author":"Barrett","year":"2006","journal-title":"Exp Physiol"},{"key":"10.1111\/ner.12758_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12576-011-0132-4","article-title":"The relationship between aortic baroreceptor activity and arterial pressure is not monotonic","volume":"61","author":"Bolter","year":"2011","journal-title":"J Physiol Sci"},{"key":"10.1111\/ner.12758_bib32","first-page":"R748","article-title":"Graded and dynamic reflex summation of myelinated and unmyelinated rat aortic baroreceptors","volume":"277","author":"Fan","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1111\/ner.12758_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.autneu.2012.10.014","article-title":"Differential distribution of voltage-gated channels in myelinated and unmyelinated baroreceptor afferents","volume":"172","author":"Schild","year":"2012","journal-title":"Auton Neurosci"},{"key":"10.1111\/ner.12758_bib34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1113\/jphysiol.1957.sp005703","article-title":"Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat","volume":"135","author":"Agostoni","year":"1957","journal-title":"J Physiol"}],"container-title":["Neuromodulation: Technology at the Neural Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fner.12758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715921018389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715921018389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ner.12758\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:55:56Z","timestamp":1761083756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094715921018389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1094715921018389"],"URL":"https:\/\/doi.org\/10.1111\/ner.12758","relation":{},"ISSN":["1094-7159"],"issn-type":[{"value":"1094-7159","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Intraneural Electrode for Bioelectronic Medicines for Treatment of Hypertension","name":"articletitle","label":"Article Title"},{"value":"Neuromodulation: Technology at the Neural Interface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ner.12758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}