{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:16:17Z","timestamp":1791656177254,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC101-2314-B-182A-004-MY3"],"award-info":[{"award-number":["NSC101-2314-B-182A-004-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3D0151"],"award-info":[{"award-number":["CMRPG3D0151"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neuromodulationjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromodulation: Technology at the Neural Interface"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1111\/ner.12853","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T12:55:01Z","timestamp":1537880101000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reversible Spasticity Suppression and Locomotion Change After Pulsed Radiofrequency on the Dorsal Root Ganglia of Rats With Spinal Cord Injury"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-5659","authenticated-orcid":false,"given":"Chia-Hsieh","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Tso","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Pin","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chii-Wann","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ner.12853_bib1","first-page":"S1","article-title":"Clinicophysiologic concepts of spasticity and motor dysfunction in adults with an upper motoneuron lesion","volume":"6","author":"Mayer","year":"1997","journal-title":"Muscle Nerve Suppl"},{"key":"10.1111\/ner.12853_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1113\/jphysiol.2006.116749","article-title":"Fiber type-specific increase in passive muscle tension in spinal-cord injured subjects with spasticity","volume":"577","author":"Olsson","year":"2006","journal-title":"J Physiol"},{"key":"10.1111\/ner.12853_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.pmrj.2009.08.002","article-title":"Spastic hypertonia and movement disorders; pathophysiology, clinical presentation, and quantification","volume":"1","author":"Sheean","year":"2009","journal-title":"PM R"},{"key":"10.1111\/ner.12853_bib4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0003-9993(99)90023-0","article-title":"Pain in persons with cerebral palsy","volume":"80","author":"Schwartz","year":"1999","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1111\/ner.12853_bib5","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1212\/WNL.0b013e3182764c86","article-title":"Poststroke spasticity: sequelae and burden on stroke survivors and caregivers","volume":"80","author":"Zorowitz","year":"2013","journal-title":"Neurology"},{"key":"10.1111\/ner.12853_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/ner.12220","article-title":"Medical cost impact of intrathecal baclofen therapy for severe spasticity","volume":"18","author":"Saulino","year":"2015","journal-title":"Neuromodulation"},{"key":"10.1111\/ner.12853_bib7","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1177\/0883073803018001S0601","article-title":"Oral pharmacotherapy of childhood movement disorders","volume":"18","author":"Edgar","year":"2003","journal-title":"J Child Neurol"},{"key":"10.1111\/ner.12853_bib8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1212\/WNL.0b013e3181cbcd2f","article-title":"Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy","volume":"74","author":"Delgado","year":"2010","journal-title":"Neurology"},{"key":"10.1111\/ner.12853_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1177\/0269215507079137","article-title":"Decrease of hypertonia after continuous passive motion treatment in individuals with spinal cord injury","volume":"21","author":"Chang","year":"2007","journal-title":"Clin Rehabil"},{"key":"10.1111\/ner.12853_bib10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1469-8749.1994.tb11864.x","article-title":"Botulinum toxin in the management of the lower limb in cerebral palsy","volume":"36","author":"Cosgrove","year":"1994","journal-title":"Dev Med Child Neurol"},{"key":"10.1111\/ner.12853_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0966-6362(99)00054-5","article-title":"Recommendations for the use of Botulinum toxin type A in the management of cerebral palsy","volume":"11","author":"Graham","year":"2000","journal-title":"Gait Posture"},{"key":"10.1111\/ner.12853_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/02699050400013675","article-title":"Botulinum toxin type A in the treatment of children and adolescents with an acquired brain injury","volume":"19","author":"van Rhijn","year":"2005","journal-title":"Brain Inj"},{"key":"10.1111\/ner.12853_bib13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00381-007-0398-2","article-title":"Selective dorsal rhizotomies in the treatment of spasticity related to cerebral palsy","volume":"23","author":"Farmer","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"10.1111\/ner.12853_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3171\/PED\/2008\/1\/3\/180","article-title":"A prospective gait analysis study in patients with diplegic cerebral palsy 20 years after selective dorsal rhizotomy","volume":"1","author":"Langerak","year":"2008","journal-title":"J Neurosurg Pediatr"},{"key":"10.1111\/ner.12853_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000120302","article-title":"Cerebral palsy spasticity, selective posterior rhizotomy","volume":"13","author":"Peacock","year":"1987","journal-title":"Pediatr Neurosci"},{"key":"10.1111\/ner.12853_bib16","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00381-007-0397-3","article-title":"Intrathecal baclofen for childhood hypertonia","volume":"23","author":"Albright","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"10.1111\/ner.12853_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1469-8749.2002.tb00267.x","article-title":"Long-term safety and efficacy of continuous intrathecal baclofen","volume":"44","author":"Campbell","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"10.1111\/ner.12853_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1526-4637.2006.00148.x","article-title":"Pulsed radiofrequency: current clinical and biological literature available","volume":"7","author":"Cahana","year":"2006","journal-title":"Pain Med"},{"key":"10.1111\/ner.12853_bib19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00000542-200501000-00021","article-title":"Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn","volume":"102","author":"Van Zundert","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1111\/ner.12853_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.surneu.2008.11.016","article-title":"Ultrastructural evaluation of pulsed radiofrequency and conventional radiofrequency lesions in rat sciatic nerve","volume":"72","author":"Tun","year":"2009","journal-title":"Surg Neurol"},{"key":"10.1111\/ner.12853_bib21","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/01.brs.0000161005.31398.58","article-title":"The histological effects of pulsed and continuous radiofrequency lesions at 42 degrees C to rat dorsal root ganglion and sciatic nerve","volume":"30","author":"Podhajsky","year":"2005","journal-title":"Spine"},{"key":"10.1111\/ner.12853_bib22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00007632-198310000-00008","article-title":"Percutaneous radiofrequency foramenal rhizotomies","volume":"8","author":"Herz","year":"1983","journal-title":"Spine"},{"key":"10.1111\/ner.12853_bib23","first-page":"319","article-title":"Percutaneous radiofrequency rhizotomy","volume":"2","author":"Uematsu","year":"1974","journal-title":"Surg Neurol"},{"key":"10.1111\/ner.12853_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00002508-199512000-00010","article-title":"Effects of producing a radiofrequency lesion adjacent to the dorsal root ganglion in patients with thoracic segmental pain","volume":"11","author":"van Kleef","year":"1995","journal-title":"Clin J Pain"},{"key":"10.1111\/ner.12853_bib25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1227\/00006123-198410000-00009","article-title":"A prospective study of radiofrequency rhizotomy in the treatment of posttraumatic spasticity","volume":"15","author":"Kasdon","year":"1984","journal-title":"Neurosurgery"},{"key":"10.1111\/ner.12853_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1090-3798(97)80044-X","article-title":"Radiofrequency lesions of the dorsal root ganglion in the treatment of hip flexor spasm: a report of two cases","volume":"1","author":"Vles","year":"1997","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1111\/ner.12853_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2377-10-52","article-title":"Percutaneous radiofrequency lesions adjacent to the dorsal root ganglion alleviate spasticity and pain in children with cerebral palsy: pilot study in 17 patients","volume":"10","author":"Vles","year":"2010","journal-title":"BMC Neurol"},{"key":"10.1111\/ner.12853_bib28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00701-010-0881-5","article-title":"Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications","volume":"153","author":"Chua","year":"2011","journal-title":"Acta Neurochir"},{"key":"10.1111\/ner.12853_bib29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1533-2500.2009.00317.x","article-title":"Ultrastructural changes in axons following exposure to pulsed radiofrequency fields","volume":"9","author":"Erdine","year":"2009","journal-title":"Pain Pract"},{"key":"10.1111\/ner.12853_bib30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/j.1532-2149.2013.00419.x","article-title":"Pulsed radiofrequency inhibited activation of spinal mitogen-activated protein kinases and ameliorated early neuropathic pain in rats","volume":"18","author":"Lin","year":"2014","journal-title":"Eur J Pain"},{"key":"10.1111\/ner.12853_bib31","first-page":"E269","article-title":"Radiofrequency on neuropathic pain: electrophysiological, molecular, and behavioral evidence supporting long-term depression","volume":"20","author":"Huang","year":"2017","journal-title":"Pain Physician"},{"key":"10.1111\/ner.12853_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuroscience.2010.01.064","article-title":"Time course quantification of spastic hypertonia following spinal hemisection in rats","volume":"167","author":"Hsieh","year":"2010","journal-title":"Neuroscience"},{"key":"10.1111\/ner.12853_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"10.1111\/ner.12853_bib34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/exnr.1996.0098","article-title":"Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transaction","volume":"139","author":"Basso","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1111\/ner.12853_bib35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1109\/TBCAS.2010.2081668","article-title":"Pain control on demand based on pulsed radio-frequency stimulation of the dorsal root ganglion using a batteryless implantable CMOS SoC","volume":"4","author":"Chiu","year":"2010","journal-title":"IEEE Trans Biomed Circuits Syst"},{"key":"10.1111\/ner.12853_bib36","first-page":"3590","article-title":"Effects of low amplitude pulsed radiofrequency stimulation with different waveform in rats for neuropathic pain","volume":"2013","author":"Lin","year":"2013","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1111\/ner.12853_bib37","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1089\/08977150260338029","article-title":"Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord: time course","volume":"19","author":"Bose","year":"2002","journal-title":"J Neurotrauma"},{"key":"10.1111\/ner.12853_bib38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuroscience.2007.07.020","article-title":"Gabapentin suppresses spasticity in the spinal cord-injured rat","volume":"149","author":"Kitzman","year":"2007","journal-title":"Neuroscience"},{"key":"10.1111\/ner.12853_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.expneurol.2010.09.019","article-title":"Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: the effects of passive exercise and modafinil","volume":"227","author":"Garrison","year":"2011","journal-title":"Exp Neurol"}],"container-title":["Neuromodulation: Technology at the Neural Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fner.12853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715921018614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715921018614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ner.12853\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:56:06Z","timestamp":1761083766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094715921018614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1094715921018614"],"URL":"https:\/\/doi.org\/10.1111\/ner.12853","relation":{},"ISSN":["1094-7159"],"issn-type":[{"value":"1094-7159","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversible Spasticity Suppression and Locomotion Change After Pulsed Radiofrequency on the Dorsal Root Ganglia of Rats With Spinal Cord Injury","name":"articletitle","label":"Article Title"},{"value":"Neuromodulation: Technology at the Neural Interface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ner.12853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}