{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:31:44Z","timestamp":1788715904045,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neuromodulationjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuromodulation: Technology at the Neural Interface"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1111\/ner.13220","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T08:23:29Z","timestamp":1592987009000},"page":"796-803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1680-6124","authenticated-orcid":false,"given":"Kai-Liang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-3417","authenticated-orcid":false,"given":"Joshua K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-2355","authenticated-orcid":false,"given":"Robert S.","family":"Eisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Carbunaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna Wagle","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-3899","authenticated-orcid":false,"given":"Adolfo","family":"Ramirez-Zamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ner.13220_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.870131303","article-title":"Consensus statement of the Movement Disorder Society on tremor. Ad Hoc Scientific Committee","volume":"13","author":"Deuschl","year":"1998","journal-title":"Mov Disord"},{"key":"10.1111\/ner.13220_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10143-015-0636-0","article-title":"Deep brain stimulation of the globus pallidus internus or ventralis intermedius nucleus of thalamus for Holmes tremor","volume":"38","author":"Espinoza Martinez","year":"2015","journal-title":"Neurosurg Rev"},{"key":"10.1111\/ner.13220_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2018.00021","article-title":"Successful treatment of Holmes tremor with deep brain stimulation of the prelemniscal radiations","volume":"5","author":"Martinez","year":"2018","journal-title":"Front Surg"},{"key":"10.1111\/ner.13220_bib4","first-page":"360","article-title":"The clinical and neuroimaging studies in Holmes tremor","volume":"122","author":"Gajos","year":"2010","journal-title":"Acta Neurol Scand"},{"key":"10.1111\/ner.13220_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/brain\/27.3.327","article-title":"On certain tremors in organic cerebral lesions","volume":"27","author":"HOLMES","year":"1904","journal-title":"Brain"},{"key":"10.1111\/ner.13220_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/1531-8249(199907)46:1<126::AID-ANA20>3.0.CO;2-3","article-title":"Function of the cerebellum in parkinsonian rest tremor and Holmes' tremor","volume":"46","author":"Deuschl","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1111\/ner.13220_bib7","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/mds.20981","article-title":"Holmes tremor: application of modern neuroimaging techniques","volume":"21","author":"Paviour","year":"2006","journal-title":"Mov Disord"},{"key":"10.1111\/ner.13220_bib8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000207201","article-title":"Thalamic deep brain stimulation for midbrain tremor secondary to cystic degeneration of the brainstem","volume":"87","author":"Sanborn","year":"2009","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1111\/ner.13220_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/jnnp.73.4.453","article-title":"Vim thalamotomy for Holmes' tremor secondary to midbrain tumour","volume":"73","author":"Kim","year":"2002","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ner.13220_bib10","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1002\/mds.10141","article-title":"Pathophysiology of nonparkinsonian tremors","volume":"17","author":"Deuschl","year":"2002","journal-title":"Mov Disord"},{"key":"10.1111\/ner.13220_bib11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1212\/WNL.0000000000002440","article-title":"Holmes tremor","volume":"86","author":"Raina","year":"2016","journal-title":"Neurology"},{"key":"10.1111\/ner.13220_bib12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00381-008-0644-2","article-title":"Deep brain stimulation for Holmes' tremor related to a thalamic abscess","volume":"24","author":"Peker","year":"2008","journal-title":"Child's Nerv Sys"},{"key":"10.1111\/ner.13220_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5334\/tohm.257","article-title":"Levodopa-responsive Holmes' tremor caused by a single inflammatory demyelinating lesion","volume":"5","author":"Katschnig-Winter","year":"2015","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"10.1111\/ner.13220_bib14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.5535\/arm.2013.37.4.591","article-title":"Holmes tremor after brainstem hemorrhage, treated with levodopa","volume":"37","author":"Woo","year":"2013","journal-title":"Ann Rehabil Med"},{"key":"10.1111\/ner.13220_bib15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/mds.24005","article-title":"Long-lasting effect of levodopa on Holmes' tremor","volume":"27","author":"Boelmans","year":"2012","journal-title":"Mov Disord"},{"key":"10.1111\/ner.13220_bib16","first-page":"810","article-title":"The treatment of posttraumatic tremor by stereotactic surgery. Symptomatic and functional outcome in a series of 35 patients","volume":"80","author":"Krauss","year":"1994","journal-title":"J\u00a0Neurosurg"},{"key":"10.1111\/ner.13220_bib17","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/jnnp.2003.023077","article-title":"Combination of thalamic Vim stimulation and GPi pallidotomy synergistically abolishes Holmes' tremor","volume":"75","author":"Goto","year":"2004","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ner.13220_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1227\/01.NEU.0000192692.95455.FD","article-title":"Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor","volume":"58","author":"Foote","year":"2006","journal-title":"Operat Neurosurg"},{"key":"10.1111\/ner.13220_bib19","series-title":"Systematic literature studies. Esem '12","first-page":"29","author":"Jalali","year":"2012"},{"key":"10.1111\/ner.13220_bib20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/jnnp-2013-305532","article-title":"The treatment of dystonic tremor: a systematic review","volume":"85","author":"Fasano","year":"2014","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ner.13220_bib21","first-page":"1025","article-title":"Multitarget, dual-electrode deep brain stimulation of the thalamus and subthalamic area for treatment of Holmes' tremor","volume":"120","author":"Kobayashi","year":"2014","journal-title":"J\u00a0Neurosurg"},{"key":"10.1111\/ner.13220_bib22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000099072","article-title":"Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor","volume":"85","author":"Lim","year":"2007","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1111\/ner.13220_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000449007","article-title":"Evolving concepts in posterior subthalamic area deep brain stimulation for treatment of tremor: surgical neuroanatomy and practical considerations","volume":"94","author":"Ramirez-Zamora","year":"2016","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1111\/ner.13220_bib24","doi-asserted-by":"crossref","first-page":"V1","DOI":"10.3171\/2017.4.FocusVid.16510","article-title":"Coaxial interleaved stimulation of the thalamus and subthalamus for treatment of Holmes tremor","volume":"42","author":"Toda","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1111\/ner.13220_bib25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S1474-4422(17)30166-7","article-title":"Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trial","volume":"16","author":"Oliveria","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1111\/ner.13220_bib26","first-page":"E445","article-title":"Ventralis intermedius plus ventralis oralis anterior and posterior deep brain stimulation for posttraumatic Holmes tremor: two leads may be better than one: Technical note","volume":"56","author":"Foote","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1111\/ner.13220_bib27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/jnnp.2008.146324","article-title":"Disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive Holmes' tremor","volume":"80","author":"Seidel","year":"2009","journal-title":"J\u00a0Neurol\u00a0Neurosurg Psychiatry"},{"key":"10.1111\/ner.13220_bib28","first-page":"1","article-title":"Holmes' tremor from a lesion of the red nucleus in association with cerebral toxoplasmosis","volume":"4","author":"Wu","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1111\/ner.13220_bib29","first-page":"485","article-title":"Dopamine deficiency in rubral tremor caused by midbrain hemangioma: case report","volume":"23","author":"Weng","year":"2000","journal-title":"Chang Gung Med J"},{"key":"10.1111\/ner.13220_bib30","first-page":"537","article-title":"Treatment responsive Holmes tremor: case report and literature review","volume":"10","author":"Alqwaifly","year":"2016","journal-title":"Int J Health Sci"},{"key":"10.1111\/ner.13220_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2015.02.003","article-title":"Toward sophisticated basal ganglia neuromodulation: review on basal ganglia deep brain stimulation","volume":"58","author":"Da Cunha","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1111\/ner.13220_bib32","first-page":"2655","article-title":"Functional segregation of basal ganglia pathways in Parkinson's disease","volume":"141","author":"Neumann","year":"2018","journal-title":"Brain"},{"key":"10.1111\/ner.13220_bib33","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/brain\/aww182","article-title":"Brain networks modulated by subthalamic nucleus deep brain stimulation","volume":"139","author":"Accolla","year":"2016","journal-title":"Brain"},{"key":"10.1111\/ner.13220_bib34","first-page":"133","article-title":"Tremor in multiple sclerosis","volume":"254","author":"Koch","year":"2007","journal-title":"J\u00a0Neurol"},{"key":"10.1111\/ner.13220_bib35","first-page":"327","article-title":"Mapping Holmes tremor circuit using the human brain connectome","volume":"27","author":"Joutsa","year":"2019","journal-title":"Ann Neurol"},{"key":"10.1111\/ner.13220_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.22361","article-title":"Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor","volume":"69","author":"Helmich","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1111\/ner.13220_bib37","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/jnnp.74.10.1387","article-title":"Multicentre European study of thalamic stimulation in essential tremor: a six year follow up","volume":"74","author":"Sydow","year":"2003","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1111\/ner.13220_bib38","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1212\/WNL.0000000000004295","article-title":"Thalamic deep brain stimulation for tremor in Parkinson disease, essential tremor, and dystonia","volume":"89","author":"Cury","year":"2017","journal-title":"Neurology"},{"key":"10.1111\/ner.13220_bib39","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/brain\/awm077","article-title":"Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor","volume":"130","author":"Herzog","year":"2007","journal-title":"Brain"},{"key":"10.1111\/ner.13220_bib40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1080\/14737175.2016.1194756","article-title":"Deep brain stimulation for the treatment of uncommon tremor syndromes","volume":"16","author":"Ramirez-Zamora","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"10.1111\/ner.13220_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mdc3.12565","article-title":"Ventral intermediate nucleus versus zona incerta region deep brain stimulation in essential tremor","volume":"5","author":"Eisinger","year":"2017","journal-title":"Mov Disord Clin Pract"}],"container-title":["Neuromodulation: Technology at the Neural Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fner.13220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ner.13220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ner.13220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715922000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094715922000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ner.13220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T22:46:40Z","timestamp":1659912400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094715922000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1094715922000022"],"URL":"https:\/\/doi.org\/10.1111\/ner.13220","relation":{},"ISSN":["1094-7159"],"issn-type":[{"value":"1094-7159","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Neuromodulation: Technology at the Neural Interface","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ner.13220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of the International Neuromodulation Society.","name":"copyright","label":"Copyright"}]}}