{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:34:35Z","timestamp":1788280475074,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Malignant peripheral nerve sheath tumors (<jats:styled-content style=\"fixed-case\">MPNSTs<\/jats:styled-content>) arising from cranial nerves are rare and usually affect adults. Here we report the clinicopathologic features of a young adult patient with a trigeminal nerve <jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>, in whom another tumor involving the oculomotor nerve on the contralateral side was evident. The patient, an 18\u2010year\u2010old woman, had suffered recurrent paroxysmal sharp stabbing pain over her cheek and forehead on the right side for 1 month. A brain MRI study disclosed a mass, 35\u2009mm in diameter, in the right <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eckel's cave, and another mass, 10\u2009mm in diameter, involving the intracranial portion of the left oculomotor nerve. Following gadolinium administration, the former and latter tumors exhibited strong and weak enhancement, respectively. The patient had no clinical stigmata characteristic of neurofibromatosis type 1. Following a tentative diagnosis of schwannoma, total resection of the trigeminal nerve tumor was performed. Histologically, the tumor consisted of highly cellular, spindle\u2010shaped cells arranged in a fascicular pattern, with occasional mitotic figures, nuclear pleomorphism and necrosis. Immunohistochemically, the tumor cells showed variable intensities and frequencies of reactivity for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010100 protein, myelin basic protein, <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content>, podoplanin and p53, but no reactivity for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>marcb1. Thus, the tumor exhibited features of <jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>. This case appears to provide information that is useful for accurate diagnosis and surgical planning in patients with bilateral or multiple cranial nerve tumors.<\/jats:p>","DOI":"10.1111\/neup.12004","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T04:36:35Z","timestamp":1356150995000},"page":"541-546","source":"Crossref","is-referenced-by-count":11,"title":["Malignant peripheral nerve sheath tumor of the trigeminal nerve: Clinicopathologic features in a young adult patient"],"prefix":"10.1111","volume":"33","author":[{"given":"Yoko","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Usuda","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Emura","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Nagaoka Red Cross Hospital  Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Kakita","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"e_1_2_7_3_1","first-page":"160","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Scheithauer BW","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930215)71:4<1247::AID-CNCR2820710413>3.0.CO;2-S"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818d6470"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.7.PEDS11151"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31820a1599"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2012.01351.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.63910"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.11.PEDS1192"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.206532"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.02.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/M7D5KTVYYE51XYQA"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0385-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181c55d55"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000062654.83617.B7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825798f1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182380802"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050475"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000318167.97966.f3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-1563-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007010170090"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.44.38"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000223498.83238.B2"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:01:29Z","timestamp":1696507289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/neup.12004"],"URL":"https:\/\/doi.org\/10.1111\/neup.12004","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}