{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T19:17:50Z","timestamp":1711739870139},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>We have reported an autopsy case of primary granulomatous angiitis of the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> preferentially involving the small veins with a granulomatous leukoencepalitis\u2010like lesion in the cerebral white matter of a 48\u2010year\u2010old man. The latter lesion was ischemic necrosis due to circumferential multiple perivenous granulomas in the adjacent <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>irchow\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>obin space. Multifocal progressive involvement of venular adventitia by granulomas, leaving behind mural fibrosis and luminal stenosis, was related clinically to the prolonged stepwise deterioration observed in the patient, and pathologically to diffuse loosening with dilated veins in the deep cerebral white matter and subcortical hemorrhagic infarction in the left parietal lobe through chronic venous stagnation. <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> demonstrated negativity for <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ropionibacterium acnes<\/jats:italic>, and <jats:italic>in situ<\/jats:italic> hybridization with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010encoded small nuclear <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> probe was also negative. The possibility of subarachnoidal latent infection with an unknown avirulent agent causing exclusively perivascular granulomas is proposed. It will be necessary to examine by autopsy whether the type (artery or vein) and size of the involved vessels and the pathological subtype of angiitis is related to the etiopathogenesis and prognosis. It is also pointed out that the entity of lymphocytic angiitis is problematic.<\/jats:p>","DOI":"10.1111\/neup.12006","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T04:37:01Z","timestamp":1356151021000},"page":"547-552","source":"Crossref","is-referenced-by-count":3,"title":["Primary granulomatous angiitis of the <scp>CNS<\/scp> preferentially involving small veins with a granulomatous leukoencephalitis\u2010like lesion in the cerebrum"],"prefix":"10.1111","volume":"33","author":[{"given":"Riki","family":"Okeda","sequence":"first","affiliation":[{"name":"Department of Pathology Kawasaki Saiwai Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kawasaki Saiwai Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koutaro","family":"Tsumura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kawasaki Saiwai Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Eishi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Tokyo Medical &amp; Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-192202000-00010"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.4.858"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052120"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01055.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01051.x"},{"key":"e_1_2_4_7_1","first-page":"41","article-title":"Granulomatous phlebitis (with giant cells), with meningeal localization","volume":"5","author":"Mestes E","year":"1968","journal-title":"Rev Roum Neurol"},{"key":"e_1_2_4_8_1","first-page":"26","article-title":"Granulomatous angiitis of the nervous system","volume":"76","author":"Budzilovich GN","year":"1963","journal-title":"Arch Pathol"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.1.198-204.2002"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.197"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70349-2"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312476"},{"key":"e_1_2_4_13_1","first-page":"382","article-title":"Mycoplasma\u2010like structures in granulomatous angiitis of the central nervous system. Case preports with light and electron microscopic studies","volume":"101","author":"Athur G","year":"1977","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687229"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200316"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:01:15Z","timestamp":1696507275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/neup.12006"],"URL":"https:\/\/doi.org\/10.1111\/neup.12006","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}