{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:42:44Z","timestamp":1696603364481},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Cryptococcal meningitis is rarely complicated by immune\u2010mediated leukoencephalopathy, but the precise pathomechanism is uncertain. A 72\u2010year\u2010old Japanese man treated with prednisolone for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weet disease developed a subacute progression of meningitis, which was considered as neuro\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weet disease. A treatment by methylprednisolone rapidly improved CSF findings with a remarkable decrease in lymphocyte numbers in the blood, but the patient's consciousness still worsened after the cessation of the treatment. The patient developed cryptococcal meningitis and MRI showed abnormal intensities predominantly in the cerebral deep white matter along with the recovery of lymphocyte numbers in the blood, which resulted in death. A postmortem examination of the brain revealed degenerative lesions, especially at the cerebral white matter and cortex adjacent to the leptomeninges abundantly infiltrated by <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcus neoformans<\/jats:italic>. In the affected cerebral deep white matter, perivascular infiltration of lymphocytes was prominent in coexistence with reactive astrocytes and vascular proliferation, but these findings were not observed in the subcortical and cortical lesions. <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcus neoformans<\/jats:italic> was not present within the brain parenchyma. This is the first report of a case suggesting that cryptococcal meningitis can accompany lymphocytic inflammation predominantly in cerebral deep white matter as a possible manifestation of immune reconstitution inflammatory syndrome.<\/jats:p>","DOI":"10.1111\/neup.12046","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T10:04:23Z","timestamp":1369044263000},"page":"45-48","source":"Crossref","is-referenced-by-count":4,"title":["Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: A possible manifestation of immune reconstitution inflammatory syndrome"],"prefix":"10.1111","volume":"34","author":[{"given":"Hiroya","family":"Kuwahara","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Neurology Yokosuka Kyosai Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zen","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Neurology Yokosuka Kyosai Hospital  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Science Graduate School Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90459-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01561.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161848.34159.B5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki444"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32834ab20a"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01852.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.02.031"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000227922.22293.93"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.105650"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:20:10Z","timestamp":1696472410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,20]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/neup.12046"],"URL":"https:\/\/doi.org\/10.1111\/neup.12046","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,20]]}}}