{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:36:06Z","timestamp":1776332166107,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Gangliogliomas are well\u2010differentiated, mixed glio\u2010neuronal tumors of the CNS that are most frequently localized within the temporal lobe. In a minority of cases, gangliogliomas have been described in the brain stem where they may critically impinge anatomical structures. Rarely, ganglioglioma develop in cranial nerves, almost exclusively in the optic pathway, where they usually present as singular space\u2010occupying masses. Here, we report on an 83\u2010year\u2010old patient who presented with unusual symmetrical, bilateral gangliogliomas of the trigeminal nerves. These tumors showed an exophytic growth within the subarachnoid space toward the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>asserian ganglion and surprisingly appeared as isointense masses on <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Due to their bilateral appearance, we performed array\u2010comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content>) on the gangliogliomas to address the possibility of an underlying tumor syndrome in this patient. To our knowledge, this is the first case of bilateral ganglioglioma of the trigeminal nerve described so far.<\/jats:p>","DOI":"10.1111\/neup.12054","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T10:36:38Z","timestamp":1375094198000},"page":"159-163","source":"Crossref","is-referenced-by-count":5,"title":["Bilateral ganglioglioma of the trigeminal nerve in an 83\u2010year\u2010old man"],"prefix":"10.1111","volume":"34","author":[{"given":"Gunnar","family":"Hargus","sequence":"first","affiliation":[{"name":"Institute of Neuropathology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bink","sequence":"additional","affiliation":[{"name":"Institute of Clinical Radiology University Clinic M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Christian\u2010Albrechts\u2010University Kiel and University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Paulus","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Harder","sequence":"additional","affiliation":[{"name":"Institute of Pathology HELIOS Klinikum Emil von Behring  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Tumors of the Central Nervous System","author":"Louis DN","year":"2007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.43151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-005-0013-3"},{"key":"e_1_2_6_5_1","first-page":"1486","article-title":"Ganglioglioma of the optic chiasm: case report and review of the literature","volume":"21","author":"Shuangshoti S","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_6_1","first-page":"1377","article-title":"Cerebellopontine angle ganglioglioma: MR findings","volume":"22","author":"Kwon JW","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690601101382"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050809"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.7.575"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0802-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318267ff55"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0020-4"},{"key":"e_1_2_6_14_1","first-page":"299","article-title":"Bilateral trigeminal schwannomas associated with von Recklinghausen disease","volume":"13","author":"Yamada K","year":"1992","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.12.1497"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.12.1892"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:10:14Z","timestamp":1696223414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,29]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/neup.12054"],"URL":"https:\/\/doi.org\/10.1111\/neup.12054","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,29]]}}}