{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:19:45Z","timestamp":1785021585759,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>A 74\u2010year\u2010old man gradually developed muscular weakness in the upper extremities, followed by dyspnea and dysarthria over a 6\u2010month period. He was admitted to our facility and diagnosed as having amyotrophic lateral sclerosis (<jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>) based on clinical and neurophysiological findings. Two months later, transtracheal positive pressure ventilation (<jats:styled-content style=\"fixed-case\">TPPV<\/jats:styled-content>) was started. During his clinical course, orthostatic hypotension occurred a few times. He also had two episodes of transient cardiac arrest, and he died 15 months after disease onset. At autopsy, the brain, weighing 850\u2009g, showed diffuse cortical atrophy, preferentially involving the frontal lobes. Microscopic findings included severe loss of neurons in the motor cortex, the motor nuclei of the brainstem and the anterior horns of the spinal cord, and mild loss of axons and myelin in the corticospinal tract. Trans\u2010activation response <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> protein 43 (<jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043) immunoreactive cytoplasmic inclusions, the pathognomonic findings for <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>, were noted in the nucleus facialis, nucleus ambiguus, and in the anterior horn of the spinal cord. In addition, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy bodies and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy neurites were found in the brainstem and in the nucleus intermediolateralis of the thoracic cord. The concomitant alpha\u2010synuclein pathology may have been partly related to possible autonomic dysfunction underlying the two episodes of cardiac arrest.<\/jats:p>","DOI":"10.1111\/neup.12057","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T01:49:06Z","timestamp":1375235346000},"page":"164-169","source":"Crossref","is-referenced-by-count":15,"title":["Concomitant alpha\u2010synuclein pathology in an autopsy case of amyotrophic lateral sclerosis presenting with orthostatic hypotension and cardiac arrests"],"prefix":"10.1111","volume":"34","author":[{"given":"Takehiro","family":"Yamada","sequence":"first","affiliation":[{"name":"Division of Neurology Ohmihachiman Community Medical Center  Ohmihachiman Japan"},{"name":"Department of Neurology Kyoto Prefectural University of Medicine  Kyoto Japan"},{"name":"Division of Neurology Kyoto First Red Cross Hospital  Kyoto 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