{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:55:43Z","timestamp":1762271743059},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,22]],"date-time":"2013-09-22T00:00:00Z","timestamp":1379808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"S<\/jats:styled-content>patacsin<\/jats:italic> (SPG11<\/jats:styled-content>) is a major mutated gene in autosomal recessive spastic paraplegia with thin corpus callosum (ARHSP\u2010TCC<\/jats:styled-content>) and is responsible for juvenile P<\/jats:styled-content>arkinsonism. To elucidate the role of spatacsin in the pathogenesis of \u03b1\u2010synucleinopathies, an immunohistochemical investigation was performed on the brain of patients with P<\/jats:styled-content>arkinson's disease (PD<\/jats:styled-content>), dementia with L<\/jats:styled-content>ewy bodies (DLB<\/jats:styled-content>) and multiple system atrophy (MSA<\/jats:styled-content>) using anti\u2010spatacsin antibody. In PD<\/jats:styled-content>, L<\/jats:styled-content>ewy bodies (LBs<\/jats:styled-content>) in the brain stem were positive for spatacsin. These LBs<\/jats:styled-content> showed intense staining in their peripheral portions and occasionally in the central cores. L<\/jats:styled-content>ewy neurites were also spatacsin\u2010positive. In DLB<\/jats:styled-content>, cortical LBs<\/jats:styled-content> were immunolabeled by spatacsin. In MSA<\/jats:styled-content>, glial cytoplasmic inclusions (GCI<\/jats:styled-content>) and a small fraction of neuronal cytoplasmic inclusions (NCI<\/jats:styled-content>) were positive for spatacsin. The widespread accumulation of spatacsin observed in pathologic \u03b1\u2010synuclein\u2010containing inclusions suggests that spatacsin may be involved in the pathogenesis of \u03b1\u2010synucleinopathies.<\/jats:p>","DOI":"10.1111\/neup.12069","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:30:43Z","timestamp":1381530643000},"page":"135-139","source":"Crossref","is-referenced-by-count":5,"title":["Immunohistochemical localization of spatacsin in \u03b1\u2010synucleinopathies"],"prefix":"10.1111","volume":"34","author":[{"given":"Satoshi","family":"Kuru","sequence":"first","affiliation":[{"name":"Department of Neurology National Organization Suzuka Hospital Suzuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging Aichi Medical School Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsui","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging Aichi Medical School Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Mimuro","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute for Medical Science of Aging Aichi Medical School Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21310"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000294327.66106.3d"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-010-0243-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm293"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.04.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0083-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23552"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61113-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.03.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_6_13_1","first-page":"879","article-title":"Aggregation of \u03b1\u2010synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba M","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00803.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140321"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0408-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.1.68"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:09:45Z","timestamp":1696223385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,22]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/neup.12069"],"URL":"https:\/\/doi.org\/10.1111\/neup.12069","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,22]]}}}