{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:56:58Z","timestamp":1770839818225,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Myeloid sarcoma (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) is a localized extra\u2010medullary tumor mass of immature myeloid cells, arising <jats:italic>de novo<\/jats:italic> or related to acute myeloid leukemia, of which it can be a forerunner, a coinciding or late event. Less commonly, <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> represents an acute blastic transformation of myelodysplastic syndromes or myeloproliferative neoplasms. This rare condition commonly consists of a proliferation of more or less immature cells with a myeloid immunophenotype, very exceptional cases showing a megakaryoblastic or erythroid differentiation. The most common localization of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> is the skin, lymph node, soft tissues and bones, but <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement is exceedingly rare, with no cases reported in the sellar region. We report a 54\u2010year\u2010old man, affected by myeloproliferative neoplasm, <jats:styled-content style=\"fixed-case\">JAK2 V617F<\/jats:styled-content>\u2010positive of 13 years duration, who acutely presented with a third cranial nerve palsy; neuroradiology documented a space\u2010occupying lesion at the level of the sellar, upper clival and right parasellar regions, that was sub\u2010totally removed with a trans\u2010sphenoidal approach. The histological examination documented a proliferation of large, blastic cells, frequently multinucleated; a diagnosis of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> with megakaryoblastic differentiation, arising in a background of chronic idiopathic myelofibrosis, was suggested by immunohistochemistry, owing to <jats:styled-content style=\"fixed-case\">CD42b<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD45<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD61<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content> (linker for activation of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells) positivity. In addition, homozygous <jats:styled-content style=\"fixed-case\">JAK2 V617F<\/jats:styled-content> mutation was detected from the myeloid sarcoma specimen. A few weeks after surgery, an acute blastic leukemic transformation occurred and, despite chemotherapy, the patient died 2 months after surgery. To the best of our knowledge, this is the first <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> case with megakaryoblastic differentiation arising within the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/neup.12071","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:51:07Z","timestamp":1381542667000},"page":"179-184","source":"Crossref","is-referenced-by-count":15,"title":["Myeloid sarcoma with megakaryoblastic differentiation mimicking a sellar tumor"],"prefix":"10.1111","volume":"34","author":[{"given":"Mariangela","family":"Novello","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology Catholic University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Coli","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Catholic University  Rome 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