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Histologically, severe myelin loss and gliosis were observed, especially in the internal capsule and cerebellum. In the lesions, severe infiltration of macrophages with broad cytoplasm filled with<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>\u2010positive and non\u2010metachromatic granules (globoid cells) was evident. On the basis of these findings, the case was diagnosed as feline globoid cell leukodystrophy (<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>rabbe's disease). 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