{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:53:37Z","timestamp":1791478417464,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Supratentorial cortical ependymoma (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>), a rare type of ependymoma, is located in the superficial cortex. We reported 11 patients (six female and five male) with <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. The age of the patients ranged from 2 to 63 years old with a median age of 47 years at the time of diagnosis. On <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, enhancement was noted in all cases with solid appearance in six cases, and solid and cystic appearance in five cases. The frontal and parietal regions were the most common locations for <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. On histology, two were low\u2010grade (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) and nine were <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> anaplastic ependymomas. Some tumors exhibited clear cell, spindle (tanycytic) and giant cell morphologies, as well as the classic ependymoma morphology. Dura\u2010based tumor nodules and even tumor dissemination along the dura can be seen in <jats:styled-content style=\"fixed-case\">CEs<\/jats:styled-content>. Low grade <jats:styled-content style=\"fixed-case\">CEs<\/jats:styled-content> have a higher likelihood to present with seizures, a lower likelihood to cause brain edema, tumor recurrence and lower mortality than anaplastic ependymomas. While difficult, anaplastic <jats:styled-content style=\"fixed-case\">CEs<\/jats:styled-content> may be distinguished from glioblastoma by a clear interface between tumor and adjacent brain tissue, relative uniformity of tumor cell nuclei and immunopositivity for epithelial membrane antigen and\/or <jats:styled-content style=\"fixed-case\">CD99<\/jats:styled-content>. As is the case for ependymomas in general, gross total resection is still the treatment of choice for <jats:styled-content style=\"fixed-case\">CEs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/neup.12087","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T07:45:30Z","timestamp":1387525530000},"page":"243-252","source":"Crossref","is-referenced-by-count":32,"title":["Supratentorial cortical ependymoma: Case series and review of the literature"],"prefix":"10.1111","volume":"34","author":[{"given":"Zhiguo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Brain Science Research Institute of Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Fan Yu District Central Hospital  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Qilu Hospital of Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Qilu Hospital of Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Famer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine North Shore\u2010Long Island Jewish Health System Hofstra North Shore\u2010LIJ School of Medicine  Lake Success New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashesh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery North Shore University Hospital  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chalif","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery North Shore University Hospital  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brain Science Research Institute of Shandong University  Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine North Shore\u2010Long Island Jewish Health System Hofstra North Shore\u2010LIJ School of Medicine  Lake Success New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"74","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"McLendon RE","year":"2007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.5.2.207"},{"key":"e_1_2_5_4_1","first-page":"79","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"McLendon RE","year":"2007"},{"key":"e_1_2_5_5_1","first-page":"1139","article-title":"[Supratentorial ectopic ependymoma: a case report]","volume":"27","author":"Saito T","year":"1999","journal-title":"No Shinkei Geka"},{"key":"e_1_2_5_6_1","first-page":"843","article-title":"[Brain surface clear cell ependymoma: case report]","volume":"27","author":"Fujimoto K","year":"1999","journal-title":"No Shinkei Geka"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2000.00355.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.42.166"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070881"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31818521cd"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000164171.29292.D6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014-007-0215-3"},{"key":"e_1_2_5_13_1","first-page":"e192","article-title":"Recurrent paediatric supratentorial extraventricular ependymoma associated with genetic mutation at exon 4 of p53 gene","volume":"49","author":"Ghani AR","year":"2008","journal-title":"Singapore Med J"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.51301"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9717-z"},{"key":"e_1_2_5_16_1","first-page":"354","article-title":"Papillary ependymoma with unique superficial cortical location: immunohistochemical and ultrastructural studies. 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