{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:21:48Z","timestamp":1769574108533,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>There is little immunohistochemical information about the early stage of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick body formation, due to the extremely limited opportunities of studying <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick's disease at the incipient or subclinical stage. We report a 62\u2010year\u2010old man without any clinical manifestations of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick's disease, who died of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma of the brainstem. Post mortem examination revealed many <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick bodies without obvious neuronal loss mainly in the left frontal and temporal lobes. Three brains of patients with typical <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick's disease (disease duration: 7, 11 and 16 years) were also examined. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick bodies were immunopositive for phosphorylated tau and 3\u2010repeat tau, and less consistently for p62 in both incipient and typical cases. In the incipient case, borderline positivity for ubiquitin was evident in only a few <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick bodies, whereas in the typical cases many <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick bodies showed obvious positivity for ubiquitin. These findings suggest that <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick bodies are rarely ubiquitinated in the early stage of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ick body formation.<\/jats:p>","DOI":"10.1111\/neup.12104","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T02:13:26Z","timestamp":1390270406000},"page":"386-391","source":"Crossref","is-referenced-by-count":13,"title":["An autopsy case of incipient <scp>P<\/scp>ick's disease: Immunohistochemical profile of early\u2010stage <scp>P<\/scp>ick body formation"],"prefix":"10.1111","volume":"34","author":[{"given":"Yasuo","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Neuropathology Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Institute of Brain Science Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"165","article-title":"Ueber die Beziehungen der senilen Hirnatrophie zur Aphasie","volume":"17","author":"Pick A","year":"1892","journal-title":"Prag Med Wochenscher"},{"key":"e_1_2_6_3_1","first-page":"123","volume-title":"Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders","author":"Bergeron 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