{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:18:59Z","timestamp":1772507939503,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Neuroenteric cysts are benign intradural endoderm cysts lined by gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) or tracheobronchial epithelial cells. Their malignant transformation is extremely rare and only six cases have been reported. In these cases, tissue lineage of the cystic endoderm cells giving rise to carcinoma was not clearly identified either as respiratory or as <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> type. Herein, we report a case of mucinous adenocarcinoma arising from the neuroenteric cyst with broncho\u2010pulmonary differentiation in the right cerebral hemisphere of a Japanese woman in her late 50s. The cyst wall was entirely lined by the following respiratory epithelial components: stratified bronchial ciliated columnar epithelium with basal cells positive for <jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content> and p63, terminal bronchiolar Clara cells positive for thyroid transcription factor (<jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>)\u20101, surfactant <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and negative for surfactant <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> pneumocytes positive for <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\u20101, negative for surfactant <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, and type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> pneumocytes positive for <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\u20101 and surfactant <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>. In addition, nests of hyperplastic single layered mucinous epithelial cells with bronchial goblet cell phenotype were also demonstrated, and histologic features were almost the same as the pulmonary type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> congenital adenomatoid malformation (<jats:styled-content style=\"fixed-case\">CCAM<\/jats:styled-content>) with mucinous epithelial proliferation. The mucinous epithelial nests of type <jats:styled-content style=\"fixed-case\">I CCAM<\/jats:styled-content> are liable to develop mucinous adenocarcinoma and frequently accompany K\u2010ras mutation and expression of p16. However, K\u2010ras mutation and p\u201016 expression were not detected in this case.<\/jats:p>","DOI":"10.1111\/neup.12118","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T07:07:58Z","timestamp":1395904078000},"page":"420-424","source":"Crossref","is-referenced-by-count":14,"title":["Mucinous adenocarcinoma arising from supratentorial intramedullary neuroenteric cyst with broncho\u2010pulmonary differentiation"],"prefix":"10.1111","volume":"34","author":[{"given":"Hidetoshi","family":"Okabe","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Department of Laboratory Medicine Shiga University of Medical Science  Otsu Japan"},{"name":"Department of Pathology Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanade","family":"Katsura","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tenjin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Japanese Red Cross Kyoto Daini Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Department of Laboratory Medicine Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Department of Laboratory Medicine Shiga University of Medical Science  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"55","volume-title":"Handbook of Clinical Neurology","author":"Wilkins RH","year":"1976"},{"key":"e_1_2_5_3_1","first-page":"2064","volume-title":"Greenfield's Neuropathology","author":"Ellison DW","year":"2008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199812000-00131"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.2.0341"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2003.00497.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000318186.10536.f6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00930.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/NPP28460"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80078-6"},{"key":"e_1_2_5_11_1","first-page":"423","article-title":"Congenital pulmonary airway malformation: a new name and expanded c1assification of congenital cystic adenomatoid malformation of the lung","volume":"41","author":"Stocker JT","year":"2002","journal-title":"Histopathology"},{"key":"e_1_2_5_12_1","first-page":"59","volume-title":"Pathology of the Lungs","author":"Corrin B","year":"2006"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2006"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00006.2010"},{"key":"e_1_2_5_15_1","first-page":"633","volume-title":"Histology for Pathologist","author":"Mills SE","year":"2012"},{"key":"e_1_2_5_16_1","first-page":"1825","article-title":"High\u2010throughput Screening Method of KRAS mutation at codon 12 and 13 in formalin \u2013fixed paraffin\u2010embedded tissue specimens of metastatic colorectal cancer","volume":"38","author":"Fukushima Y","year":"2011","journal-title":"Jpn J Cancer Chemother"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100003553"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200409000-00008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000249444.90594.27"},{"key":"e_1_2_5_20_1","first-page":"2597","article-title":"Mucinous bronchioloalveolar carcinoma with K\u2010ras mutation arising in type 1 congenital cystic adenomatoid malformation; 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