{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:01:12Z","timestamp":1790917272258,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    Coxsackievirus\n                    <jats:styled-content style=\"fixed-case\">B4<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">CB4<\/jats:styled-content>\n                    ) is a picornavirus associated with a variety of human diseases, including neonatal meningoencephalitis, myocarditis and type 1 diabetes. We report the pathological findings in twin newborns who died during an acute infection. The twins were born 1 month premature but were well and neurologically intact at birth. After a week they developed acute lethal neonatal sepsis and seizures. Histopathology demonstrated meningoencephalitis and severe myocarditis, as well as pancreatitis, adrenal medullitis and nephritis. Abundant\n                    <jats:styled-content style=\"fixed-case\">CB4<\/jats:styled-content>\n                    sequences were identified in nucleic acid extracted from the brain and heart.\n                    <jats:italic>In situ<\/jats:italic>\n                    hybridization with probes to\n                    <jats:styled-content style=\"fixed-case\">CB4<\/jats:styled-content>\n                    demonstrated infection of neurons, myocardiocytes, endocrine pancreas and adrenal medulla. The distribution of infected cells and immune response is consistent with reported clinical symptomatology where systemic and neurological diseases are the result of\n                    <jats:styled-content style=\"fixed-case\">CB4<\/jats:styled-content>\n                    infection of select target cells.\n                  <\/jats:p>","DOI":"10.1111\/neup.12121","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T04:10:42Z","timestamp":1396843842000},"page":"429-437","source":"Crossref","is-referenced-by-count":52,"title":["Coxsackievirus\n                    <scp>B4<\/scp>\n                    myocarditis and meningoencephalitis in newborn twins"],"prefix":"10.1111","volume":"34","author":[{"given":"Stephanie J.","family":"Bissel","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin C.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"DelTondo","sequence":"additional","affiliation":[{"name":"Allegheny County Medical Examiner  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoji","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Williams","sequence":"additional","affiliation":[{"name":"Allegheny County Medical Examiner  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton A.","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Infectious Diseases of the Central Nervous System","author":"Tyler KL","year":"1993"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280601090546"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1408-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ANC.0000296631.80926.8d"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70194-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.19-6-183"},{"key":"e_1_2_6_8_1","first-page":"1577","article-title":"Nonpolio enterovirus and human parechovirus surveillance \u2013 United States, 2006\u20132008","volume":"59","author":"Centres for Disease Control (CDC)","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_9_1","first-page":"515","article-title":"Epidemiologic, clinical, and laboratory features of Coxsackie B1\u2010B5 infections in the United States, 1970\u201379","volume":"99","author":"Moore M","year":"1984","journal-title":"Public Health Rep"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01907.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280902913263"},{"key":"e_1_2_6_12_1","first-page":"258","article-title":"MRI of acute disseminated encephalomyelitis after coxsackie B infection","volume":"20","author":"David P","year":"1993","journal-title":"J Neuroradiol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308928"},{"key":"e_1_2_6_14_1","first-page":"1090","article-title":"Liquefactive necrosis in Coxsackie B encephalitis","volume":"110","author":"Estes ML","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_15_1","first-page":"741","article-title":"An immunofluorescent study of generalized Coxsackie virus B3 infection in a newborn infant","volume":"35","author":"Iwasaki T","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.12.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700442104"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00452061"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1297-z"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.151.3709.447"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.47.59"},{"key":"e_1_2_6_22_1","first-page":"331","article-title":"Pathological changes in the pancreas of mice following infection with Coxsackie B viruses","volume":"57","author":"Lansdown AB","year":"1976","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20303"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280591002531"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64915-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00378-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00514.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-47"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5725-09.2010"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(03)00035-X"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0127"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(96)01398-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.05.018"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.064"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4430-4440.2002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63496-7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-10.2010"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/314032"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e318163a990"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00067-6"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.01.015"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02837.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11583"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139522"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.23.5018"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:59:54Z","timestamp":1696208394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,7]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/neup.12121"],"URL":"https:\/\/doi.org\/10.1111\/neup.12121","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,7]]}}}