{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T04:29:27Z","timestamp":1722227367657},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>This study was done to evaluate the association of cyclooxygenase 2 (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102) and brain fatty acid binding protein (<jats:styled-content style=\"fixed-case\">BFABP<\/jats:styled-content>) with tumor grade and outcome of grades <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> meningiomas treated with radiotherapy. From 1996 to 2008, 40 patients with intracranial grades <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> meningiomas were treated with radiotherapy. Immunohistochemical staining for <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">BFABP<\/jats:styled-content> were performed on formalin\u2010fixed paraffin\u2010embedded tissues. <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression was significantly associated with <jats:styled-content style=\"fixed-case\">BFABP<\/jats:styled-content> status and both <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and <jats:styled-content style=\"fixed-case\">BFABP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) expression were stronger in the grade <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> meningiomas than in grade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> tumors. Among the clinicopathologic factors, age and <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 status were prognostic in progression\u2010free survival. Patients with moderate or strong <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression had worse outcome than those with negative or weak <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression (<jats:italic>P<\/jats:italic>\u2009=\u20090.03) after controlling for potential confounders. Our results suggest that the molecular biomarker <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 has prognostic significance in intracranial grades <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> meningiomas following radiotherapy.<\/jats:p>","DOI":"10.1111\/neup.12128","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T08:49:12Z","timestamp":1398847752000},"page":"446-454","source":"Crossref","is-referenced-by-count":11,"title":["Immunohistochemical analysis of cyclooxygenase\u20102 and brain fatty acid binding protein expression in grades <scp>I<\/scp>\u2010<scp>II<\/scp> meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy"],"prefix":"10.1111","volume":"34","author":[{"given":"Hyun\u2010Cheol","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Seoul National 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