{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:47:30Z","timestamp":1773866850937,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>A 29\u2010year\u2010old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> SCAN and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> demonstrated a cystic\u2010solid contrast\u2010enhancing sellar\u2010suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed a typical appearance of adamantinomatous craniopharyngioma. The patient received gamma knife therapy after his first operation because of partial tumor removal. He experienced two relapses in the subsequent 2 years, for which only surgical resection was performed. The later histopathology presented malignant appearance with tumor cells moderate to severe pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio, high mitotic activity (30\/10 high power fields) and focal coagulative necrosis. The patient died 9 months after identification of histologic malignancy. Clinical and histopathological features, biological behavior of one case of malignant craniopharyngioma were discussed, with a brief review of the relevant literature.<\/jats:p>","DOI":"10.1111\/neup.12142","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T02:45:21Z","timestamp":1407811521000},"page":"50-55","source":"Crossref","is-referenced-by-count":15,"title":["Malignant transformation of craniopharyngioma with detailed follow\u2010up"],"prefix":"10.1111","volume":"35","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Min","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010jun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Yun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pathology Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Xia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangzhou Liuhuaqiao Hospital  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"843","article-title":"Malignant changes in a craniopharyngioma","volume":"15","author":"Akachi K","year":"1987","journal-title":"No Shinkei Geka"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802d8a96"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00986.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.9.PEDS09257"},{"key":"e_1_2_5_6_1","first-page":"723","article-title":"Craniopharyngioma with malignant transformation\u2010a report of two cases","volume":"35","author":"Suzuki F","year":"1989","journal-title":"Gan No Rinsho"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(99)90019-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690400012400"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_2_5_10_1","first-page":"1427","article-title":"Craniopharyngioma: radiologic and histologic findings and recurrence","volume":"17","author":"Eldevik OP","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_11_1","first-page":"461","volume-title":"Craniopharyngioma. 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