{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:16:18Z","timestamp":1762298178952},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Brain metastasis is an uncommon but increasing manifestation of ovarian epithelial carcinoma and neuropathologists' collective experience with these tumors is limited. We present clinicopathological characteristics of 13 cases of brain metastases from ovarian epithelial carcinoma diagnosed at two academic institutions. The mean ages at diagnosis of the ovarian carcinoma and their subsequent brain metastases were 58.7 and 62.8 years, respectively. At the time of initial diagnosis of ovarian carcinoma the majority of patients had an advanced stage and none had brain metastases as their first manifestation of malignancy. Brain metastases tended to be multiple with ring\u2010enhancing features on neuroimaging. Primary tumors and their brain metastases were all high\u2010grade histologically and the histologic subtypes were: nine high\u2010grade serous carcinoma (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>) cases, two clear cell carcinoma (<jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>) cases and a single case each of carcinosarcoma and high\u2010grade adenocarcinoma. A recommended histo\u2010 and immunopathological approach to these tumours are provided to aid neuropathologists in the recognition and classification of metastatic ovarian carcinoma to the brain.<\/jats:p>","DOI":"10.1111\/neup.12172","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T03:15:07Z","timestamp":1415330107000},"page":"122-129","source":"Crossref","is-referenced-by-count":10,"title":["Metastatic ovarian carcinoma to the brain: An approach to identification and classification for neuropathologists"],"prefix":"10.1111","volume":"35","author":[{"given":"Houman","family":"Nafisi","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cesari","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Karamchandani","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Laboratory Medicine St. Michael's Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathiri","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Lee","family":"Keith","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis 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