{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:45:40Z","timestamp":1696315540233},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Neurogenic pulmonary edema (<jats:styled-content style=\"fixed-case\">NPE<\/jats:styled-content>) is a clinical syndrome characterized by the acute onset of pulmonary edema following a significant central nervous system insult. Only a few cases of <jats:styled-content style=\"fixed-case\">NPE<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcal meningitis have been reported. We report a case of <jats:styled-content style=\"fixed-case\">NPE<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcal meningoencephalitis. A 40\u2010year\u2010old man with no medical history was hospitalized for disturbance of consciousness. Blood glucose level was 124\u2009mg\/dL. Non\u2010contrast head computed tomography showed no abnormalities. Lumbar puncture revealed a pressure of over 300\u2009mm <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>O<\/jats:roman><\/jats:styled-content> and cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) confirmed a white blood cell count of 65\/mm<jats:sup>3<\/jats:sup>. The <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> glucose level was 0\u2009mg\/dL. The patient was empirically started on treatment for presumptive bacterial and viral meningitis. Four days after, the patient died in a sudden severe pulmonary edema. Autopsy was performed. We found at autopsy a brain edema with small hemorrhage of the right basal ganglia, severe pulmonary edema and mild cardiomegaly. Histologically, dilated <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>irchow\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>obin spaces, crowded with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococci were observed. In the right basal ganglia, <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>irchow\u2010<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>obin spaces were destroyed with hemorrhage and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococci spread to parenchyma of the brain. No inflammatory reaction of the lung was seen. Finally, acute pulmonary edema in this case was diagnosed as <jats:styled-content style=\"fixed-case\">NPE<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ryptococcal meningoencephalitis. After autopsy, we found that he was positive for serum antibodies to human immunodeficiency virus.<\/jats:p>","DOI":"10.1111\/neup.12193","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T11:37:54Z","timestamp":1430998674000},"page":"343-347","source":"Crossref","is-referenced-by-count":1,"title":["Neurogenic pulmonary edema following <scp>C<\/scp>ryptococcal meningoencephalitis associated with <scp>HIV<\/scp> infection"],"prefix":"10.1111","volume":"35","author":[{"given":"Reiichiro","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Fukuoka Japan"},{"name":"Cancer Center  Fukuoka Japan"},{"name":"Department of Diagnostic Pathology Kurume University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Fukuoka 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