{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:50:58Z","timestamp":1784638258079,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011709","name":"Beijing Institute for Brain Disorders","doi-asserted-by":"crossref","award":["BIBD-PXM2013_014226_07_000084"],"award-info":[{"award-number":["BIBD-PXM2013_014226_07_000084"]}],"id":[{"id":"10.13039\/501100011709","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Technology Research and Development Program of the Ministry of Science and Technology of China","award":["2013BAI09B03"],"award-info":[{"award-number":["2013BAI09B03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>We investigated the clinicopathologic features and immunophenotypes of 10 cases of endolymphatic sac tumor (<jats:styled-content style=\"fixed-case\">ELST<\/jats:styled-content>) and compared them with other papillary tumors, including eight cases of choroid plexus papilloma (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>), three cases of atypical choroid plexus papilloma (<jats:styled-content style=\"fixed-case\">ACPP<\/jats:styled-content>), two cases of papillary ependymoma (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>), three cases of papillary meningioma (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) and two cases of metastatic carcinoma (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) the at cerebellopontine angle (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>). The age at onset of <jats:styled-content style=\"fixed-case\">ELST<\/jats:styled-content> ranged from 13 to 39 years. The male\u2010to\u2010female ratio was 1:1. The clinical presentations were primarily ear\u2010related symptoms. The temporal bones showed extensive destruction. Histologically, the important characteristics for differential diagnosis with <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>, which is most similar to <jats:styled-content style=\"fixed-case\">ELST<\/jats:styled-content>, include the quantity of blood vessels, the nuclei location at apical surface of the papillary, clear cytoplasm cells sometimes with visible vacuoles, psammoma bodies and dura or bone invasion. Immunohistochemistry stains for <jats:styled-content style=\"fixed-case\">AE1\/AE3<\/jats:styled-content>, cytokeratin <jats:styled-content style=\"fixed-case\">CK)5<\/jats:styled-content>\/6, epithelial membrane antigen, <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content>\/18, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010100, and synaptophysin are helpful in diagnosis of <jats:styled-content style=\"fixed-case\">ELST<\/jats:styled-content>. In <jats:styled-content style=\"fixed-case\">ELST<\/jats:styled-content>, ultrastructure of uniform 2\u2009\u03bcm vesicles in cytoplasm was seen, and gene analysis also showed missense mutation in exon 3. This study indicates that the above histological features combined with immunohistochemistry findings are important for making the correct diagnosis. Gene analysis should be used in patients without medical history to exclude von Hippel\u2010Lindau disease.<\/jats:p>","DOI":"10.1111\/neup.12200","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T06:51:29Z","timestamp":1430895089000},"page":"410-420","source":"Crossref","is-referenced-by-count":21,"title":["Clinicopathologic study of endolymphatic sac tumor (<scp>ELST<\/scp>) and differential diagnosis of papillary tumors located at the cerebellopontine angle"],"prefix":"10.1111","volume":"35","author":[{"given":"Jiang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Neuropathology Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing 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Microscopy Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglin","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Beijing Neurosurgical Institute Capital Medical University China National Clinical Research Center for Neurological Diseases NCRC\u2010ND Center of Brain Tumor Beijing Institute for Brain Disorders Beijing Key Laboratory of Brian Tumor  Beijing 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