{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:20:40Z","timestamp":1771550440585,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG05681, P01 AG03991, P01 AG26276, U01 AG032438, U01 AG024904, P30-NS048056"],"award-info":[{"award-number":["P50 AG05681, P01 AG03991, P01 AG26276, U01 AG032438, U01 AG024904, P30-NS048056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"ALzheimer's Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"AstraZeneca AB"},{"name":"Bristol-Myers Squibb"},{"name":"Eisai Global Clinical Development"},{"name":"Elan Corporation plc"},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005632","name":"Forest Laboratories","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005632","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute for the Study of Aging"},{"name":"Merck and Co. Inc."},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004319","name":"Pfizer Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wyeth Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"It has been hypothesized that the relatively rare autosomal dominant A<\/jats:styled-content>lzheimer disease (ADAD<\/jats:styled-content>) may be a useful model of the more frequent, sporadic, late\u2010onset AD<\/jats:styled-content> (LOAD<\/jats:styled-content>). Individuals with ADAD<\/jats:styled-content> have a predictable age at onset and the biomarker profile of ADAD<\/jats:styled-content> participants in the preclinical stage may be used to predict disease progression and clinical onset. However, the extent to which the pathogenesis and neuropathology of ADAD<\/jats:styled-content> overlaps with that of LOAD<\/jats:styled-content> is equivocal. To address this uncertainty, two multicenter longitudinal observational studies, the A<\/jats:styled-content>lzheimer D<\/jats:styled-content>isease N<\/jats:styled-content>euroimaging I<\/jats:styled-content>nitiative (ADNI<\/jats:styled-content>) and the D<\/jats:styled-content>ominantly I<\/jats:styled-content>nherited A<\/jats:styled-content>lzheimer N<\/jats:styled-content>etwork (DIAN<\/jats:styled-content>), leveraged the expertise and resources of the existing K<\/jats:styled-content>night A<\/jats:styled-content>lzheimer D<\/jats:styled-content>isease R<\/jats:styled-content>esearch C<\/jats:styled-content>enter (ADRC<\/jats:styled-content>) at W<\/jats:styled-content>ashington U<\/jats:styled-content>niversity S<\/jats:styled-content>chool of M<\/jats:styled-content>edicine, S<\/jats:styled-content>t. L<\/jats:styled-content>ouis, M<\/jats:styled-content>issouri, USA<\/jats:styled-content>, to establish a N<\/jats:styled-content>europathology C<\/jats:styled-content>ore (NPC<\/jats:styled-content>). The ADNI\/DIAN\u2010NPC<\/jats:styled-content> is systematically examining the brains of all participants who come to autopsy at the 59 ADNI<\/jats:styled-content> sites in the USA<\/jats:styled-content> and C<\/jats:styled-content>anada and the 14 DIAN<\/jats:styled-content> sites in the USA<\/jats:styled-content> (eight), A<\/jats:styled-content>ustralia (three), UK<\/jats:styled-content> (one) and G<\/jats:styled-content>ermany (two). By 2014, 41 ADNI<\/jats:styled-content> and 24 DIAN<\/jats:styled-content> autopsies (involving nine participants and 15 family members) had been performed. The autopsy rate in the ADNI<\/jats:styled-content> cohort in the most recent year was 93% (total since NPC<\/jats:styled-content> inception: 70%). In summary, the ADNI\/DIAN NPC<\/jats:styled-content> has implemented a standard protocol for all sites to solicit permission for brain autopsy and to send brain tissue to the NPC<\/jats:styled-content> for a standardized, uniform and state\u2010of\u2010the\u2010art neuropathologic assessment. The benefit to ADNI<\/jats:styled-content> and DIAN<\/jats:styled-content> of the implementation of the NPC<\/jats:styled-content> is very clear. The NPC<\/jats:styled-content> provides final \u201cgold standard\u201d neuropathological diagnoses and data against which the antecedent observations and measurements of ADNI<\/jats:styled-content> and DIAN<\/jats:styled-content> can be compared.<\/jats:p>","DOI":"10.1111\/neup.12205","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T10:56:50Z","timestamp":1431428210000},"page":"390-400","source":"Crossref","is-referenced-by-count":77,"title":["Neuropathologic assessment of participants in two multi\u2010center longitudinal observational studies: The A<\/scp>lzheimer D<\/scp>isease N<\/scp>euroimaging I<\/scp>nitiative (ADNI<\/scp>) and the D<\/scp>ominantly I<\/scp>nherited A<\/scp>lzheimer N<\/scp>etwork (DIAN<\/scp>)"],"prefix":"10.1111","volume":"35","author":[{"given":"Nigel J.","family":"Cairns","sequence":"first","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Neuropathology Department of Pathology & Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Neuropathology Department of Pathology & Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin E.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Carter","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Neuropathology Department of Pathology & Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Vincent","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Neuropathology Department of Pathology & Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammie","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Radiology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Friedrichsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda M.","family":"Halliday","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health University of Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Neurology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Neuropathology Department of Pathology & Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Dominantly Inherited Alzheimer Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.09.172"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4155\/cli.12.93"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0358-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00058-4"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"S1","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease","volume":"18","year":"1997","journal-title":"Neurobiol Aging"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S347"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0237-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0612-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.250"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0311-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-010-9210-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.025"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21843"},{"key":"e_1_2_6_20_1","first-page":"1257","article-title":"Predominant deposition of amyloid\u2010beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene","volume":"148","author":"Mann DM","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(91)90006-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00245-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.3.707"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051\u20105960\u20101\u201065"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:48:19Z","timestamp":1696279699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/neup.12205"],"URL":"https:\/\/doi.org\/10.1111\/neup.12205","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}