{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T05:06:25Z","timestamp":1722488785168},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) involvement by metastatic cancer is well\u2010recognized and typically presents with multifocal solid tumors within the brain parenchyma or leptomeningeal dissemination. We describe herein a histologically very rare case of <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> metastasis in a 52\u2010year\u2010old woman who presented with mental status changes. Post mortem examination revealed extensive <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement by metastatic inflammatory breast carcinoma, characterized by the presence of single tumor cells diffusely present within capillaries without parenchymal or perivascular invasion, and acute ischemic changes\/infarcts bilaterally involving multiple areas. The cancer cells were found predominantly in the cerebral cortices and deep gray matter structures. Pre\u2010mortem magnetic resonance and <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> imaging of the brain did not identify metastatic cancer; however, widespread ischemic changes (i.e. brain infarcts) were identified. Inflammatory breast carcinoma is well\u2010known to have a predilection for spread through lymphovascular spaces. Post mortem examination revealed tumor involvement of bilateral lungs, heart and bladder, with sinusoidal spread in the liver and lymph nodes and prominent involvement of the splenic red pulp in addition to extensive vascular involvement of the brain and spinal cord without a discrete mass, despite the presence of widely metastatic disease. The tumor cells in the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> were strongly immunoreactive for pancytokeratin, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010cadherin, cytokeratin\u20107, epithelial membrane antigen and <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> 5.2. This unique histologic pattern of tumor spread is considered to represent \u201cintravascular carcinomatosis\u201d in the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>, and most likely the cause of the patient's widespread ischemic injuries.<\/jats:p>","DOI":"10.1111\/neup.12206","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T04:08:40Z","timestamp":1430280520000},"page":"456-461","source":"Crossref","is-referenced-by-count":4,"title":["Intravascular carcinomatosis of central nervous system due to metastatic inflammatory breast cancer: A case report"],"prefix":"10.1111","volume":"35","author":[{"given":"Hidehiro","family":"Takei","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Rouah","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Barrios","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.175"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2008.00338.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0152-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00782.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.9.858"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji172"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt206"},{"key":"e_1_2_6_9_1","first-page":"3857","article-title":"Microvessel density, expression of estrogen receptor alpha, MIB\u20101, p53, and c\u2010erbB\u20102 in inflammatory breast cancer","volume":"8","author":"McCarthy NJ","year":"2002","journal-title":"Clin Cancer Res"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:19:56Z","timestamp":1696252796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/neup.12206"],"URL":"https:\/\/doi.org\/10.1111\/neup.12206","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"value":"0919-6544","type":"print"},{"value":"1440-1789","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,28]]}}}