{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T01:27:34Z","timestamp":1760318854598,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26860655","26430050","26430049","24300131"],"award-info":[{"award-number":["26860655","26430050","26430049","24300131"]}]},{"name":"Hirosaki University Institutional Research"},{"name":"Collaborative Research Project"},{"name":"Brain Research Institute, Niigata University","award":["2014-2508"],"award-info":[{"award-number":["2014-2508"]}]},{"DOI":"10.13039\/501100014731","name":"Research Committee for Ataxic Disease","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014731","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Grant","award":["24-5"],"award-info":[{"award-number":["24-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Nuclear receptor subfamily 4, group <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, member 3 (<jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content>), also known as neuron\u2010derived orphan receptor\u20101, is a nuclear receptor which plays key roles in cell cycle, neuronal differentiation, apoptosis and metabolism. These processes may be involved in the pathogenesis of certain neurodegenerative diseases. Previous studies have shown that there are high levels of <jats:styled-content style=\"fixed-case\">NR4A3 mRNA<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>. Moreover, <jats:styled-content style=\"fixed-case\">NR4A2<\/jats:styled-content>, a transcription factor with homology to <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content>, has been reported to contribute to the pathogenesis of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease. However, it is uncertain whether <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> is also involved in diseases such as dementia with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy bodies, multiple system atrophy, and other neurodegenerative disorders such as tauopathies, <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043 proteinopathies and polyglutamine diseases. In the present study we used immunohistochemistry to examine the brain and spinal cord from patients with various neurodegenerative diseases and normal control subjects using two polyclonal anti\u2010<jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> antibodies. In controls, the cytoplasm of neurons and glial cells was faintly immunostained with anti\u2010<jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> antibodies. In tissues from patients with neurodegenerative diseases, immunoreactivity for <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> was observed in cortical and brainstem\u2010type <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy bodies in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's disease and in dementia with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ewy bodies, as well as in neuronal and glial cytoplasmic inclusions in multiple system atrophy. A double\u2010labeled immunofluorescence study showed co\u2010localization of <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> and phosphorylated \u03b1\u2010synuclein in these inclusions. Neuronal and glial inclusions in other neurodegenerative disorders were <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> negative. These findings suggest that accumulation of <jats:styled-content style=\"fixed-case\">NR4A3<\/jats:styled-content> is specific to \u03b1\u2010synucleinopathy.<\/jats:p>","DOI":"10.1111\/neup.12210","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T23:51:56Z","timestamp":1434757916000},"page":"503-509","source":"Crossref","is-referenced-by-count":8,"title":["Localization of nuclear receptor subfamily 4, group A, member 3 (<scp>NR4A3<\/scp>) in <scp>L<\/scp>ewy body disease and multiple system atrophy"],"prefix":"10.1111","volume":"35","author":[{"given":"Tomoya","family":"Kon","sequence":"first","affiliation":[{"name":"Department of Neuropathology Hirosaki University Graduate School of Medicine  Hirosaki Japan"},{"name":"Department of Neurology Aomori Prefectural Central Hospital  Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of 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