{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:23:49Z","timestamp":1740126229012,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>The histopathologic presentation of varicella\u2010zoster virus (VZV) infection of the central nervous system is varied and is not well understood. Here we report a case of VZV encephalomyelitis with prominent demyelinating pathology in a patient with a history of follicular lymphoma treated with allogeneic stem cell transplantation. The patient presented with waxing and waning bilateral limb weakness and mental status changes. MRI showed leptomeningeal, peripheral spinal cord and periventricular cerebral white matter lesions in the brain, and polymerase chain reaction on cerebrospinal fluid detected VZV DNA. The patient expired from developing atrial fibrillation that rapidly progressed to ventricular fibrillation 10\u2009days after admission to our hospital. Autopsy revealed macrophage\u2010rich areas of demyelination in the spinal cord and cerebrum with relative preservation of axons associated with inclusion bodies and positive immunostaining for VZV. This case represents a rare example of VZV encephalomyelitis presenting with a predominantly demyelinating, \u201cmultiple sclerosis\u2010like\u201d pathology. The clinical and histopathologic findings and relevant literature are presented and discussed.<\/jats:p>","DOI":"10.1111\/neup.12224","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T13:04:13Z","timestamp":1435323853000},"page":"587-591","source":"Crossref","is-referenced-by-count":7,"title":["Varicella\u2010zoster virus encephalomyelitis with a prominent demyelinating component"],"prefix":"10.1111","volume":"35","author":[{"given":"Sarah","family":"Berth","sequence":"first","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olimpia","family":"Carbunar","sequence":"additional","affiliation":[{"name":"Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning Sarah","family":"Yang","sequence":"additional","affiliation":[{"name":"Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Fredericks","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard L.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Neurology"},{"name":"Microbiology and Immunology University of Illinois at Chicago, College of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-584X","authenticated-orcid":false,"given":"Tibor","family":"Valyi\u2010Nagy","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420906"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000092"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.987"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.3.1181"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.10.1818"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.04.017"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31829ecb98"},{"volume-title":"Neuropathology: A reference text of CNS pathology, 3rd edition ed","year":"2013","author":"Ellison D","key":"e_1_2_4_9_1"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b477"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460200051005"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290049004"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687229"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.45.1.94"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212966.60383.74"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06044"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290520"}],"container-title":["Neuropathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fneup.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/neup.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:17:46Z","timestamp":1696198666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/neup.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/neup.12224"],"URL":"https:\/\/doi.org\/10.1111\/neup.12224","archive":["Portico"],"relation":{},"ISSN":["0919-6544","1440-1789"],"issn-type":[{"type":"print","value":"0919-6544"},{"type":"electronic","value":"1440-1789"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}