{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:32:01Z","timestamp":1774470721458,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Gliosarcomas are a variant of glioblastomas and present a biphasic pattern, with coexisting glial and mesenchymal components. In this study, two unusual cases are presented. Case 1 is a 52\u2010year\u2010old woman with a headache and memory disturbance for a month. Case 2 is an 18\u2010year\u2010old man with a headache lasting two weeks. In both cases, an MRI revealed enhancing T1\u2010low to iso, T2\u2010iso to high intensity lesions in the pineal gland region. Histologically, in case 1, the tumor showed spindle cell proliferation with disorganized fascicles and cellular pleomorphism. Tumor cells variously exhibited oncocytic transformation. Immunohistochemically, most of the spindle tumor cells were positive for myoglobin and desmin. Some of the tumor cells were positive for GFAP and S\u2010100 protein. On the other hand, all tumor cells were positive for CD133, Musashi1, and SOX\u20102 which are the markers of neural stem cells. In case 2, the tumor showed monotonous proliferation of short spindle cells with disorganized fascicles and cellular atypism. The morphological distinction between glial and mesenchymal components was not apparent. Immunohistochemically, most of the spindle tumor cells were positive for desmin. Glial tumor cells that were dispersed within the sarcoma as single cells were positive for GFAP. In addition, all tumor cells were positive for CD133, Musashi1 and SOX\u20102. Based on these microscopic appearances, and immunohistochemical findings, these cases were diagnosed as gliosarcomas arising from the pineal gland region. These results also indicated that pluripotential cancer stem cells differentiated into glial and muscle cell lines at the time of tumor growth. In a survey of previous publications on gliosarcoma arising from the pineal gland, these cases are the second and third reports found in English scientific writings.<\/jats:p>","DOI":"10.1111\/neup.12226","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T12:40:11Z","timestamp":1437050411000},"page":"56-63","source":"Crossref","is-referenced-by-count":12,"title":["Gliosarcomas arising from the pineal gland region: uncommon localization and rare tumors"],"prefix":"10.1111","volume":"36","author":[{"given":"Yasuo","family":"Sugita","sequence":"first","affiliation":[{"name":"Departments of Pathology Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuhiko","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Departments of Pathology Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Kurume University School of Medicine  Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Mary's Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Mary's Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Mary's Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Mary's Hospital  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"48","volume-title":"WHO Classification of tumours of the Central Nervous System","author":"Kleihues P","year":"2007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.55418\/9781933477015","volume-title":"Tumors of the Central Nervous System","author":"Burger PC","year":"2007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0790-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900301)65:5<1161::AID-CNCR2820650522>3.0.CO;2-F"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.5858\/2006-130-1208-GWFOOO","article-title":"Gliosarcoma with features of osteoblastic sarcoma","volume":"130","author":"Barresi V","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5858\/2006-130-381-GWLDTN","article-title":"Gliosarcoma with liposarcomatous differentiation. 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