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Previously, we demonstrated antibody\u2010enhanced dengue disease (ADE) dengue in an immunocompetent mouse model with a dengue virus 2 (DENV2) antibody injection followed by DENV3 virus infection. Here we migrated this ADE model to <jats:italic>Callithrix penicillata<\/jats:italic>. To mimic human multiple infections of endemic zones where abundant vectors and multiple serotypes co\u2010exist, three animals received weekly subcutaneous injections of DENV3 (genotype III)\u2010infected supernatant of C6\/36 cell cultures, followed 24\u2009h later by anti\u2010DENV2 antibody for 12 weeks. There were six control animals, two of which received weekly anti\u2010DENV2 antibodies, and four further animals received no injections. After multiple infections, brain, liver, and spleen samples were collected and tissue was immunolabeled for DENV3 antigens, ionized calcium binding adapter molecule 1, Ki\u201067, TNF\u03b1. There were marked morphological changes in the microglial population of ADE monkeys characterized by more highly ramified microglial processes, higher numbers of trees and larger surface areas. These changes were associated with intense TNF\u03b1\u2010positive immunolabeling. It is unclear why ADE should generate such microglial activation given that IgG does not cross the blood\u2010brain barrier, but this study reveals that in ADE dengue therapy targeting the CNS host response is likely to be important.<\/jats:p>","DOI":"10.1111\/neup.12229","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T02:21:40Z","timestamp":1440469300000},"page":"3-16","source":"Crossref","is-referenced-by-count":10,"title":["Antibody\u2010enhanced dengue disease generates a marked CNS inflammatory response in the black\u2010tufted marmoset <i>Callithrix penicillata<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"Barbara Cristina Baldez","family":"Vasconcelos","sequence":"first","affiliation":[{"name":"Universidade do Estado do Par\u00e1, UEPA, Centro de Ci\u00eancias da Sa\u00fade, Curso de Gradua\u00e7\u00e3o em Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana 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